Ca-AKG and ageing markers – what the latest data suggests

Posted by ivy_mobility in Research & News - 2 points, 4 comments.

I came across a recent preprint looking at calcium alpha‑ketoglutarate and its impact on biological‑age clocks in middle‑aged adults. The study measured a few epigenetic markers before and after 12 weeks of 2 g daily Ca‑AKG, reporting a modest shift toward younger‑looking profiles. For me the idea of tweaking a Krebs‑cycle intermediate to influence ageing feels plausible, especially since I’ve noticed slightly better recovery and less joint stiffness when I’ve taken Ca‑AKG intermittently over the past few months. That said, the change in the clocks was small and could easily be within normal variation or driven by lifestyle tweaks during the trial period.

Comments

• aspiring_trailrun: I’ve packed a 2 g bottle of Ca‑AKG into my daily routine for the last six months. The joint stiffness that usually follows a long training session feels a touch less pronounced, and my soreness lasts a day shorter – but I’ve also been eating more greens and hitting a stricter sleep schedule, so it’s hard to pin the improvement solely on the supplement. The epigenetic clock shift in that preprint is very modest; in my own quick chalk‑board maths it could fall inside the normal 5‑10 % variation yo
• ivy_mobility: Great to hear the joint relief, aspiring_trailrun. I’ve been on 2 g each day for 12 weeks and did notice a similar reduction in stiffness, but I didn’t log my greens or sleep strictly, so it’s similar to your situation. In the preprint the subjects had no dietary controls – just self‑reported intake. Do you keep a meal log? That could help isolate the effect. Also, how have you been measuring soreness duration?
• aspiring_trailrun: I’ve been taking Ca‑AKG for a couple of months now, mostly after my runs, so I can relate. I’ve felt my joints a touch softer and soreness dropping a little faster, but I haven’t changed my diet or sleep much beyond that. The preprint’s 12‑week clock shift is interesting; in my own data the marker swings can be as wide as a week’s training load change, so a small shift isn’t a slam‑dab. It’s worth watchingংশ how consistent dosing and a regular recovery plan play into the numbers.
• ivy_mobility: That’s reassuring to hear – I’ve also noticed the joints feel a bit looser after Ca‑AKG. In my own routine I dose 2 g daily for 12 weeks and track a recovery log with sleep and HRV. I’m curious if you’ve mapped your marker dwóch swings to training load days; could the wide ± week swings you see line up with hard runs? ⚖️🏃

Community discussion - research and educational context only. Not medical advice.