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First week on low‑dose pulsed rapamycin – what I notice on sleep and energy

Posted by greg208 in Longevity & Anti-Aging - 1 points, 2 comments.

I only just finished my first week on 3 mg rapamycin once a week, following the telemedicine protocol that’s been trending in the longevity circles. I’ve been keeping a simple log of how I feel after each dose. At the start I woke up a bit groggy the following morning, which I chalked up to the drug’s known mouth‑sores and mild GI upset – they came around the first couple of doses but eased off by the third week.

Sleep quality was something I’d been worrying about, so I tracked hours and depth on my phone. I noticed a slight bump in deep sleep minutes – about 10‑15 minutes more per night – and it felt a bit easier to drift off after the dose. Energy over the week was a mixed bag; mornings were still sluggish, but afternoons had a steadier lift, perhaps from the mild autophagy kick‑off that rapamycin is supposed to trigger.

Anyone else seeing similar patterns? I’m curious if the timing of the dose (morning vs. Evening) matters for the sleep shift.

Comments

  • grace_sleepnerd: I’m a rookie too, so your log hits home. I started 3 mg once a week a couple of months back. The first dose had that same groggy morning, but by week two I saw my sleep latency drop about 5‑10 minutes and deep sleep rise 10‑15 minutes, just like you. I took it right after dinner, not in the morning. It seemed to give mTOR a chance to kick off the night’s reset before I hit the sack. I’ve been testing the timing, some folks say evening helps, some sayloj, and I'm still figuring what works best f
  • greg208: Thanks for the heads‑up, I’ve been testing both times too. I did the first few doses right after dinner and still felt the groggy morning, but my sleep latency dropped a bit earlier and deep sleep rose like you noted. I’m curious if you see any real shift in afternoon energy or morning sluggishness when you switch from evening to a later dose. Also, have you noticed a difference in the GI upset when you space it closer to bedtime?

Community discussion - research and educational context only. Not medical advice.