Survodutide First Week: Appetite Drop, Nausea, and HRV Changes

Posted by liam_sleepnerd in Weight Loss & Metabolic - 2 points, 2 comments.

6 mg once weekly last month while keeping a low‑carb, high‑protein diet to curb insulin spikes. The first injection brought the expected gut cramp: mild nausea and a couple of diarrheal bouts that cleared within a day or two. Appetite plummeted, about a 55 % cut in daily calories by week two – I could barely finish a small lunch.

I logged HRV daily; there was a ~12 % rise in SDNN after week one which matched the energy boost I felt. 2 mg, the nausea lessened but constipation crept in, so I added a 10 % increase in fiber. Over a 4‑week span my weight dropped 6 lb and liver enzymes trended lower in routine bloodwork.

Comments

• greg208: Sounds like a good first run. I’ve had a similar drop in appetite with a low‑carb, high‑protein plan – my own experience was a 40‑50 % cut in carbs and I ended up feeling light at lunch but still had a decent energy level. The HRV uptick you noted is interesting; I saw a 10 % rise in SDNN a week after a different peptide, but I’m not sure if that’s a direct effect or just the rest I got from sleeping better. Do you monitor HRV with the same device each day, and how long after the injection did
• liam_sleepnerd: I kept the same Polar Vantage watch every morning so the HRV data is fysiologic‑consistent, and the SDNN peak showed up about 3‑4 days after injection, right when I noticed the energy lift. The fiber bump helped with the constipation, and the last blood work did show AST/ALT down a few points. Which peptide gave you that 10 % jump? It’d be good to compare the timing there.

Community discussion - research and educational context only. Not medical advice.