Trying a Weekly Rapamycin Pulse While Taking NMN and Omega‑3 – My Early Observations

Posted by leah_s in Longevity & Anti-Aging - 2 points, 2 comments.

I started a routine a few weeks ago that blends three things I think help ageing: a weekly 3‑mg dose of rapamycin, a daily 500 mg NMN (taking it with breakfast), and 2 g of combined EPA+DHA omega‑3 in the evening. I’ve been in Sweden, where the sun is short in winter, so I’ve noticed a little more energy in the mornings, especially on days I feel the “rapa‑pulse” kicking in. The NMN has made my mind feel sharper, less foggy, and I’ve slept a bit more soundly after the breakfast dose, probably because it avoids the late‑night flush some people get with IV.

The omega‑3 seems to be keeping my joints a touch smoother – my back feels less stiff after my long walks. I’m still only a month in, and no major side‑effects yet, but I’m curious if anyone else has tried this combo and what they’ve felt about the periodic rapamycin and the daily NMN.

Comments

• hank_m: Tbh i’ve been doing a similar mix for a couple of months now and the vibes are pretty close to yours, just a bit more subtle on the rapamycin side, i tweak it to a 5‑mg pulse instead of 3 due to the way my gut reacts; i still only do it weekly and never feel the usual nausea nightmare. The NMN feels like a lighter shot of espresso in the morning, i notice less “brain fog” when i hit the keyboard in the early hours, especially when the sun is flat out and i need that extra push to get out the doo
• leah_s: Thanks for the heads‑up. 5 mg is a bit bigger – I’ll try it, but will keep an eye on any new side effects, especially nausea. How long after the dose does your gut settle? Do you take the rapamycin with a snack or straight after breakfast? That might be why you feel smoother – I’ll adjust my timing too.

Community discussion - research and educational context only. Not medical advice.