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Clomiphene in men: new study shows fertility kept, but still cautious?

Posted by hank_m in Research & News - 5 points, 5 comments.

gov/37312345/). 5 mg with standard intramuscular testosterone enanthate in men with low T. The authors say the clomiphene group had similar improvements in mood, energy, and libido, but most importantly their sperm counts stayed intact while the TRT group saw a drop.

Tbh i’m excited about the fertility angle because i’ve heard a lot of people fear losing their testicular function when they start TRT, and this అభ proves there’s a viable alternative that keeps the sperm factory running. I’ve never taken clomiphene myself, but i’ve experimented with low‑dose testosterone for a short time and noticed a weird drop in libido after a few weeks, so i might try the SERM route next. 5 or start lower and step up?

Also, anyone know if this holds up in a longer‑term real‑world setting? Looking forward to your thoughts.

Comments

  • weekendnate: Alemanha, the study is interesting, but for me it’s still a “maybe” check. I’ve been on low‑dose testosterone for a couple of months, and the drop in libido you mentioned felt real, not just placebo. 5 mg, and it seemed to keep my testosterone up while my mood stayed stable. My sperm count didn’t budge, and I didn’t notice any fatigue. I’d still বাঁঅ get a baseline and do weekly labs, andalcool talk to a doctor before stepping up. Long‑term data are thin, so keep a close eye on your endocrine p
  • hank_m: I hear you on the 5 mg point, that’s the sweet spot for most of us on low–dose TRT, i’ll do a baseline and weekly labs before bumping it up, tbh i’m a bit nervous about the long‑term side effects you mentioned, and i’d love to know if you’ve noticed any changes after 3 months of staying steady.
  • hank_m: Tbh i’ve been on low‑dose TRT for a few months too and felt that slump in libido, so i tried clomiphene after seeing the study, and my mood and sperm count stayed steadier, but i still do weekly labs and keep my doctor in the loop.
  • student_rational: I’ve been on a similar low‑dose TRT + clomiphene combo for about six weeks and noticed my mood stayed up and my sperm count didn’t drop, though I got a slight headache the first week. I also keep weekly labs and check in with my doctor.
  • hank_m: Thanks for the heads up student_rational tbh the headache in week one was something i had a mild case of when i first tried testosterone 50 mg, and i’ve been monitoring my labs weekly too so i’m glad you’re doing that, it’s the only way to stay sure the clomiphene is keeping the sperm factory humming, i’ll try 5 mg starting low like you and bump up only if the labs stay good, what dose did you pick?

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