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Injectable ALA: My experience with dosing and side effects

Posted by aspiring_trailrun in General Discussion - 1 points, 2 comments.

I started a course of injectable R‑Alpha‑Lipoic Acid from a telemedicine clinic last month, mainly to tackle the tingling and numbness I’ve been feeling in my feet after long runs. The clinic recommended 200 mg once a week, but I eventually settled on 400 mg two times a week once I noticed a mild nausea on the days I took it. The half‑life is only about 30 minutes orally, but with the IM route it seems to linger a bit longer, so I can finish the injection early in the evening and still feel a subtle energy lift through the night.

The tingling has eased considerably, and the mild fatigue I used to feel after training sessions is less pronounced. I have, however, had a flat‑baked after‑taste and a faint skin rash the first week, which resolved once I pushed the dose up a notch. I’m curious if anyone else has used the injectable form at a higher frequency (three times a week) and what their experience has been with that approach.

Comments

  • hank_m: Tbh i’ve never taken injectable ALA but i’ve been on oral and it’s a bit different – the injections stay in your system longer so the energy lift you mentioned sounds plausible, i’ve felt that with my own 2‑week v‑c booster, the lag is gone and i sleep better – the taste you got is a classic nod to the paracetamol‑like carbonyl residues, i’ve had that in my own injections. I’ve tried a 3x‑weekly scheme with 200 mg and the nausea was a round‑trip – you can taper it down to 150 mg on the third day
  • aspiring_trailrun: Sounds like the tapering trick could work for my rash. I’ll try 3× weekly, 200 mg first two days, then 150 mg on the third. Should the 150 mg be in the morning or late afternoon? I noticed the flat‑baked after‑taste was strongest right հայտնում after the first dose; did yours fade as the week went on? Also, did you see a noticeable lift when you switched to 300 mg a day?

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