ResearchSafe

Pregnenolone 50 mg – my experience with mood and memory over a month

Posted by aspiring_trailrun in General Discussion - 6 points, 4 comments.

I started taking 50 mg of pregnenolone every morning last month to see if it would settle my racing thoughts after a hectic week at work. The first few days I noticed a mild headache that faded after the day went on, probably the brain clearing its own endocannabinoid mess. By week two I felt the mental fog lift Tuple; clarity crept in during meetings and I could finish a block of training plans without the usual fuzz.

I also began to notice a slight lift in my overall mood, a quiet boost that helped after a long run. No acne or insomnia, and I didn’t feel jittery. I stopped it after a month to see if it was just a placebo, and the clarity did take a step back. I’m curious if anyone else has tried the 50 mg dose for the same effects or if you notice stronger side-effects mie like irritability or over‑stimulation.

Comments

  • grace_sleepnerd: I’m down in the same boat. I kicked 30 mg in my morning coffee last fall and got a quick headache that chose to chill after the first hour. After a week the mental fog started to thin out, and I could draft my whole sprint plan without that “brain‑fog” feel. Mood lift was subtle, almost like a quiet “okay” rather than a high. I never hit jitter or acne. I’d love to hear if anyone’s seeing irritability or a spike in energy, maybe it’s dose or timing. IMO it might help with the post‑run wind‑down
  • aspiring_trailrun: No jitter, just the same calm lift you mentioned. I noticed the clarity slips when I skip a day or stop for a week. Do you feel any change in wind‑down after runs? Any time tweaks that help?
  • brandon_p: Hey grace_sleepnerd, I’ve had the same quick headache that fades after the first hour and the fog lifts by the second week. I never noticed jittery or acne, just a calm steadiness. Have you tried moving the dose to the evening to see if the post‑run wind‑down feels smoother? Also, any irritability when you bump the dose?
  • aspiring_trailrun: Brandon, thanks for the note. I manj not yet tried an evening split; I’m leaning to it because my runs finish around 7 pm and the morning dose leaves me quite focused but still a bit alert afterwards. I’d like to see if a post‑run dose smooths the wind‑down. I’ve kept the 50 mg steady, so I haven’t seen irritability – but I’d love to hear if anyone’s tried 75 mg and felt a spike.

Community discussion - research and educational context only. Not medical advice.