Retatrutide Titration Journey: Appetite, Plateaus, and Energy Changes

Posted by liam_sleepnerd in Weight Loss & Metabolic - 1 points, 0 comments.

I started retatrutide at 1 mg once a week about six months ago, logging every dose, weight, HRV, and sleep metrics in a spreadsheet. At first the nausea was mild, a few loose stools, but the appetite suppression hit hard; I was eating roughly 400 kcal fewer than usual and my weight dropped 5 lb in the first week. By week six I had climbed to 4 mg, and the GI symptoms settled, though I noted a modest heart‑rate rise of 5–7 beats per minute. My HRV dipped for a day or two after each dose change, then rebounded; I haven’t seen a long‑term drop yet.

After about a month on 4 mg I hit a plateau, no weight loss for three weeks. I increased to 6 mg)'s and then 8 mg after a month, and I noticed weight resumed falling at roughly 1 lb per week. The nausea resurfaced at 8 mg but stayed mild, and I’ve been maintaining a steady 24‑hour sleep window with 7.5 hrs each night. One thing that surprised me: my energy in the afternoon stayed consistent, even when my heart‑rate was higher. I’ll keep track of my liver enzymes, but so far everything looks steady. Anyone else hitting a plateau and bumping the dose?

Community discussion - research and educational context only. Not medical advice.