Tesofensine რამდენად ზრდის წონასწორობა და რక్తწნობის ცვლილება

Posted by greg208 in Safety & Side Effects - 4 points, 4 comments.

25 mg daily dose of Tesofensine perfecte, because the appetite suppression sounded great and the weight loss numbers from the papers line up. After about a month I noticed a mild dry mouth that got worse as the day went on, and then the next morning my cuff read 145/88 when it used to be around 130/70. I checked a few more readings over the next week – they stayed in the mid‑140s systolic, a jump of about 15‑20 mmHg.

Worst of all the rest of the day I felt a little lightheaded when standing up fast, so I stopped the dose for a week and the readings dropped back to baseline. I’m not a cardiologist, but it does make me think twice about using a monoamine reuptake inhibitor when I have any hypertension risk. If you’ve tried Tesofensine and seen a similar rise in blood pressure, or if you’re already on meds that affect BP, do you think it’s worth adjusting the dose or adding a heart‑rate monitor? Any daily monitoring tips or anecdotal safety tweaks would be handy.

Comments

• student_rational: I’ve tried Tesofensine in Thema’s group a few times and noticed a similar uptick in BP. For me the change was about 10‑15 mmHg systolic, usually in the early afternoon. I ended up spacing the dose to 8 am instead of noon and kept a log of readings every 3 hours on a phone app. If you’re on meds for BP or have a history, I’d recommend a quick talk with a pharmacist or doctor before changing doses. A wearable HR monitor can catch drops when you stand up, just keep an eye on the trend, not a singl
• greg208: Thanks for the tip, I’ll try the 8 am split and jot down readings every 3 hrs like you did. I’m curious if you noticed any drop in appetite or energy that early – my experience was a bit flat in the morning, so maybe the timing changes that. Also, what phone app did you use to keep the log? It’ll help me keep it simple.
• ivy_mobility: I’ve seen the same rise when I took it midday, switching to a 7 am dose flattened the curve for me. Logging every few hours helped spot the pattern, and a simple wrist‑band HRV tracker caught the post‑stand dip before I felt it. Did you notice any change in sleep quality with the earlier dose? ⚖️👀
• greg208: That 7 am switch worked for me too – the numbers flattened and I didn’t feel the post‑stand dip as badly. I didn’t notice a dramatic shift in sleep quality, maybe a few more awakenings but nothing major. I’ll start logging HRV with my watch every 4‑hour and see if the morning dose keeps the trough lower. Could you share what HRV trend you saw right after the dose?

Community discussion - research and educational context only. Not medical advice.