ResearchSafe

Got joint pain after first IGF‑1 LR3 dose – is that normal?

Posted by grace_sleepnerd in Safety & Side Effects - 6 points, 6 comments.

I started a Performance Stack last month – 100 mcg of follistatin, 50 mcg of IGF‑1 LR3 and 200 mcg of MGF post‑workout, plus nightly CJC‑1295/Ipamorelin. About a week in, I felt a sharp ache in my knees and shoulders that wasn’t there before. I checked my fasting glucose the next day; it was 98 mg/dL, so no hypoglycemia, but the pain was persistent for a couple of days.

From reading the stack profile, joint discomfort is listed among the side effects, supposedly from rapid strength gains. I’ve heard others say it’s common, but I’m not sure if it’s a sign I should pause or just accept the trade‑off. I’m also checking if a lower IGF‑1 dose or adding a prophylactic anti‑inflammatory might help. Anyone else experienced this? How did you manage it? I’m looking for practical tweaks, not a cure‑all.

Comments

  • hank_m: Tbh i hit a similar snag a few months back when i cranked up rbh4 and then added a shot of IGF‑1. My knees went on a wild pivot for a week, feels like the weights were suddenly heavier. I didn’t shut the stack down, just cut the IGF‑1 by వారు…50 mcg and added a daily 100 mg diclofen consectetur‑like anti‑inflammatory. The ache eased in 48 hrs and my strength gains stayed. Maybe keep an eye on joint soreness and tweak the dose, or just give your ligaments time to adapt. I’d love to hear how you’
  • medic_derek: Tbh sounds like a solid-descent plan – you cut the IGF and added a big‑dose anti‑inflammatory, got the pain gone in a couple days and kept the lifts. I’d be curious how the diclofenac worked out long‑term, was there any rebound pain once you stopped it? Also did you notice any change in recovery or soreness the week after the tweak?
  • aspiring_trailrun: I’ve been in the same boat. After cutting IGF‑1 to 25 mcg and taking a low dose of a diclofenac‑based anti‑ Akk, the joint ache faded within 48 hrs. I still push the same volume, but I add a warm compress after each session to give the ligaments a breather.
  • grace_sleepnerd: Thanks for the tip, I’ll cut IGF‑1 to 25 mcg and hit a low dose of diclofenac, can you share the exact mg you’re taking? I’ll also start the warm compress afterSharpen. I’m curious if you noticed any impact on the strength gains when you lowered the IGF‑1; did the jumps in strength still feel as big but the pain stayed mild?
  • grace_sleepnerd: I cut IGF‑1 to 25 mcg and started diclofenac 50 mg three times a day for 5 days. The knee/shoulder ache cleared in 48 hrs and I didn’t feel a rebound once I stopped it. Recovery still feels the same; I notice a touch more muscle soreness after hard sets but nothing off. What dosing schedule do you recommend for long‑term use?
  • grace_sleepnerd: Thanks for the heads‑up, Hank. I’ll drop my IGF‑1 from 50 mcg to 25 mcg and start a 100 mg daily anti‑inflammatory, but I’m not sure if you’re talking ibuprofen, naproxen or a COX‑2 drug. Did you feel any stomach upset or blood pressure changes with the diclofen‑like dose? Also, did the strength gains stay steady with the lower IGF‑1?

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