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Survodutide Titration and Appetite Response – Thoughts for a New Compound

Posted by liam_sleepnerd in Weight Loss & Metabolic - 7 points, 4 comments.

I’ve been digging into Survodutide, the dual GLP‑1/Glucagon agonist that’s supposed to cut appetite while ramping up hepatic fat oxidation. 6 mg. For me, the key question is how quickly to bump the dose while watching for nausea or GI upset – the glucagon kick can throw a wrench into the digestive system.

I’ve got HRV and sleep data on my phone, so I’m costes to see if a higher dose dips my HRV or messes with my recovery. I’ve heard anecdotal reports of a 3‑week plateau where weight loss stalls but appetite stays low; that might mean the energy‑expansion part is kicking in and my body is shifting fuel usage. 8 mg) or jump more aggressively?

Also, any data on how much liver‑fat reduction actually shows up in quick imaging or bloodwork? I’m looking to add a variable to my protocol next month, so any practical insights from early real‑world use would help me design a safer titration schedule.

Comments

  • greg208: I’ve been on Survodutide for about four weeks and it’s a bit of a dance. I started at 6 mg and only increased to 7 mg after the first week because my stomach was still ranking up. The nausea usually fades after a couple of doses so I usually give it a week or two before bumping again. I’ve been watching HRV on my phone and it hasn’t dipped noticeably with the 7 mg dose – if anything, my recovery feels a touch smoother when I hit 8 mg, but I kept the jump slow to stay on the safe side. I’ve seen
  • liam_sleepnerd: I’ve noted your 4‑week run, starting 6 mg and moving to 7 mg after week 1 because of the stomach ranking up, and that HRV stayed flat while you say recovery feels “touch smoother” at 8 mg – that’s an interesting hint that the glucagon drive isn’t hurting autonomic tone for you. You mentioned a modest liver‑fat drop; did you get a quick ultrasound or just a trend in ALT/AST? I’m planning a 3‑week plateau before the next bump, so a concrete time‑point on when you saw the first measurable fat loss
  • grace_sleepnerd: Thanks for the update, Greg. I’m still on 6 mg and only went to 7 mg after a week of mild nausea, so your timing matches mine. HRV stayed flat for me too, and I actually noticed a small bump in sleep quality at 8 mg. Will keep an eye on the liver enzymes, caution is key.
  • liam_sleepnerd: Got it, tbh I also held off on a jump until week two after a mild bout of nausea at 6 mg, then nudged to 8 mg. My HRV stayed within 2 % of baseline and the PSQI score rose 3 points right after the 8 mg boost. 2× the upper limit before each rise. How long after a dose change did you notice any shift in your liver enzymes or waist circumference?

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