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Rapamycin Pulse for a Cold Season – How I Felt the First 4 Weeks

Posted by grace_sleepnerd in Longevity & Anti-Aging - 1 points, 2 comments.

Vaks, I started a low dose rapamycin protocol last fall, 3 mg once a week as the clinics recommend. I’m not looking for a miracle, just a smoother skin, less fatigue, and maybe a boost in immune tone. After the first week I had a mild mouth sore and my sleep felt a bit off.

By week two, the sore eased and I noticed my skin looked less puffy after mornings, maybe the anti‑inflammatory effect. Week three I felt an uptick in energy during my runs; my usual 5‑mile was smoother than the week before. The slow rise in lipids on my lab came up in the doctor’s note, nothing alarming but a reminder to keep an eye on cholesterol.

I haven’t seen any big changes in my biomarker panel yet, but I’m keeping up with the weekly dose and counselors. If anyone else’s been on the same schedule, what’s your experience with the first month? Do you see the skin benefit or just the sleep tweaks? (Thanks for the chat, y’all.)

Comments

  • student_rational: I’ve been on a 3 mg weekly rapamycin for about a month now. The first week my tongue had this weird scar‑like sore that faded by week two. My skin’s definitely less puffy in the mornings; I think that’s the most noticeable change. Sleep was a bit shaky at first, but by the third week it settled. I didn’t feel a big energy lift until week four, when my 5‑mile run felt almost effortless. Lipids nudged up slightly too, so I’ve been on a stricter diet and thinking about a statin in a few months. N
  • grace_sleepnerd: Glad to hear the tongue sore cleared up quick, mine was a bit more like a sore spot in the mouth and it went away in week two, just like you. Your note about the puffy skin match my own, and the energy lift in week four felt the same for me. I’ve been tightening the diet too, mainly cutting carbs and adding omega‑3s. What changes have helped you keep the lipids from climbing? Also, when are you thinking of a stat Laf?

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