How did my first week of low‑dose rapamycin feel?

Posted by greg208 in Longevity & Anti-Aging - 1 points, 0 comments.

I started the 4‑mg weekly plan two months ago, aiming to chase the autophagy boost I read about. The first dose was right after a full night of sleep – I don't do much more than a cup of tea before bed. Within a couple of days I noticed my muscles feeling slightly sore, a bit like a post‑run chill, but no sharp pain.

I also had mild mouth soreness that lasted a day or two, which was the only side effect I could pick out. No rash or GI upset, but I did feel a teensy bit of fatigue in the evenings, which I think is normal because we’re forcing cells to clean up. I’ve been keeping a log – just a few lines each day – and overall sleep quality stayed the same, but I’ve noticed that my pillow has a bit of an edge now: a lighter, more airy feel.

I haven’t hit any measurable changes in energy yet, but it’s early and the dosage is low. Does anyone else notice the same mild soreness the first week? I’m curious if the effect is uniform or if it really takes a couple of cycles to kick in.

Community discussion - research and educational context only. Not medical advice.