Pramlintide injection site pain after first week – anything to reduce it?

Posted by greg208 in Safety & Side Effects - 5 points, 6 comments.

I’ve just been using pramlintide 20 mcg before every major meal for అ up to a month now. The first few days were fine but after a week my injection sites on the abdomen have been sore, occasionally a bit swollen, and a sharp prick pain that lingers for a while. I’m not entirely sure if this is normal or if I’m doing something wrong – panan?

I’ve tried rotating sites and using the 1 ml pen as instructed, but the pain persists. I’ve also read that some people get mild bruising or redness, but I thought I’d mention that it’s a bit more intense than I’d expected. Does anyone else experience similar injection‑site issues?

Any tips on technique, cooler gel, or if it’s worth waiting longer to see if it improves on its own? I’ve got my bloodwork scheduled next week, so hoping to keep it under control.

Comments

• student_rational: I’ve been shooting the same 20 mcg before meals and got a lot of that same “sharp prick that lingers” after a week. I started using a cold gel pack for a minute before each shot and a tiny massage afterward – it cut the soreness in half. I also switched to 30 ° angle instead of straight‑down and never stuck two injections in the same spot for more than 48 h. If the pain stays, maybe ask your provider to check the needle gauge or if the dose feels right. Keep the log and bring it up at your bloo
• hank_m: DEV, i’ve tried the 30 ° angle and an ice pack too – tbh it helped a bit with the sharp prick, but the swelling still lingers, especially after a full month. I’ve not switched needle gauges yet, but my doc suggested a 31G instead of 30G, so i’ll give that publié a shot. How’s that working for you?
• hank_m: Tbh that cold pack and angle tweak was a game changer for me too, but i noticed the sting lingered a bit after i’d been using the same spot for over 48 hrs, so i started spacing the shots a day or two apart and the pain dropped. Do you keep a log of exactly where you rotate?
• greg208: I do keep a log – I tick off the exact spot on a small chart and move 2–3 cm each time. I’ve tried the cold pack and angle tweak you mention, but the soreness still lingers even after spacing shots a day or two apart. I usually inject on the outer right side of the abdomen. What angle do you find works best? Will a slightly shallower trick help?
• greg208: Thanks for the quick reply, hank_m. I’m still on the 30G needle and 30° angle with the ice pack, so the prick is sort of dulled but the swelling is stubborn, especially after the month mark you mentioned. Switching to 31G sounds sensible – plan to try it next injection. Got any experience with a different pen size or tech for the swelling? Also, any tips on post‑injection massage or temperature that help?
• greg208: Thanks for the quick reply. I’ll start angling at 30° and squeeze a chilled gel for a minute before each shot, then give the site a quick rub. I paisaje the pen uses a 29‑gauge needle, so just double‑check that. Do you think the pain maybe came from a sharper needle or from using the same site too often? I’ll log every change until the bloodwork next week.

Community discussion - research and educational context only. Not medical advice.