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Camaro 15 mg Tirzepatide, plateau and nausea after 4 months

Posted by liam_sleepnerd in Weight Loss & Metabolic - 5 points, 6 comments.

I began compounded tirzepatide at 2.5 mg weekly six months ago, logging weight, HRV, and GI symptoms daily. After 8 weeks I titrated to 5 mg, saw a steady drop of 3 kg, and HRV increased from 48 ms to 65 ms. At week 12 I pushed to 10 mg, weight fell another 2 kg, but nausea became constant, especially after meals. The GI side‑effects peaked around week 14, but my HRV dipped back to 55 ms, and the weight loss plateaued at a 12 % total from baseline.

I elected to hold at 10 mg for two more weeks, which helped the nausea ease, but the weight stayed flat. Then I reduced to 7.5 mg and noticed appetite returning slightly, and weight began to creep down again, now 0.5 kg in the last week. My question: have others hit a similar plateau at 10 mg and found that a small de‑titration helps break it? Also, did anyone use any supportive GI meds without compromising the metabolic benefits? I stay off OTC anti‑emetics and keep a low‑carb dinner to see if that mitigates nausea while still staying in the weight‑loss window.

Comments

  • kayla_s: I hit a similar spot around 10 mg. 5 mg for a week and the appetite nudged back up enough to keep losing a few pounds, but the weight fell off the straight line a bit. I didn’t use any strong anti‑emetics, but I did start taking a small dose of ginger tea after mealsilus thru a broth, and it seemed to soften the gut upset without taste‑bending my appetite. I also kept the evenings low‑carb and added a probiotic capsule. If you can, talk to your prescriber about tweaking the dose or splitting th
  • hank_m: Tbh i’ve tried ginger tea after meals too, it softened nausea a touch but didn’t kill the appetite spike, so i cut carbs at night and added a probiotic capsule, feeling a bit steadier, and i asked my doc about splitting the dose and maybe a low‑dose antihistamine to see if that eases the gut.
  • hank_m: Tbh i tried ginger tea after meals for a couple weeks at 10 mg, noticed less nausea and appetite stayed up, but weight didn’t budge much. Splitting the dose wasn’t huge help, but a low‑dose antihistamine helped my stomach settle. Keep an eye on hrv.
  • liam_sleepnerd: Tbh I already slipped a cup of ginger tea in after meals when I hit 10 mg, so that’s a no‑frills method I can stay on. I’m curious about the low‑dose antihistamine, you said it helped your stomach settle; did it change your appetite or weight at all? I’ll monitor HRV, but I’ll try matching your antihistamine protocol for a week to see if the plateau eases.
  • liam_sleepnerd: Thanks, Hank, for the ginger tea tip, my chamomile rinse after meals felt similar, a bit less nausea but still not zero. I’m picking up the same probiotic you mentioned, so will log its effect next week. Splitting the 10 mg into two 5 mg shots won’t change my appetite yet, but I’ll try the low‑dose antihistamine and see if it eases the gut.
  • liam_sleepnerd: Sounds good about the 5 mg dip, tbh I cut back to 7.5 mg but the appetite jump was slow, so a quick 5 mg week might work. I’ll try ginger tea after meals and keep the evenings low‑carb like you did.％What probiotic capsule did you use, and did that help the nausea more than the ginger? A mild pro‑kinetic is on my list too.

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