ResearchSafe

4-aco-dmt: a more stable psilocybin pro‑drug catching attention

Posted by hank_m in Research & News - 1 points, 2 comments.

I read the article on the /peptides/4-aco-dmt page that talks about 4‑AcO‑DMT being a lab‑made cousin of psilocybin which gets converted to psilocin in the body, and i was intrigued by the claim that it’s a more stable alternative. The paper cites a few small human studies that show similar visual and emotional effects to mushrooms but with less nausea, and the half‑life appears a bit longer – between two to three hours – which could make dosing a bit smoother. From my own early experiments with psilocybin, i know how variable the onset can be depending on the batch and gut flora, so a pro‑drug that reliably converts to the active compound sounds handy, especially for those who want a predictable psychedelic window for therapy or research.

The downside i see is the lack of long‑term safety data and that it still trips on 5‑HT2A receptors, so the risk of anxiety or heart rate spikes remains. Any of you have tried a stable pro‑drug like this, or any strategy to mitigate the “bad trip” potential?

Comments

  • student_rational: I’ve been on the same cusp for a while. In my early mushroom runs I’d always notice how the first dose could feel almost immediate, but the next batch could take a full hour to hit, gut flora, hydration, even the cup of coffee you had that day mattered. A pro‑drug that slides straight into psilocin sounds slick, especially if you’re looking for a cleaner, longer window for a therapeutic session. That said, the only thing I’ve seen about 4‑AcO‑DMT is the short‑term vibe, no data on what happens
  • hank_m: I hear you on the coffee‑fluide bit afectar; i found that same 60‑minute lag after the first 2‑gram run before the next 1‑gram dose snapped on, probably gut algo. 2‑mg 4‑AcO‑DMT yesterday with a small grind of coffee, hit the peak around 90 min and it held for 2½ hrs, no spike in HR. I’m still cautious about monthly repeats but it felt steadier than the raw brew. What’s your go‑to dose?

Community discussion - research and educational context only. Not medical advice.