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Apigenin: Sleep aid or NAD+ protector? My take after reading the latest news

Posted by greg208 in Research & News - 1 points, 2 comments.

org about apigenin and its dual role as a mild anxiolytic and CD38 inhibitor. org/peptides/apigenin. For me, the idea that a single compound could both ease my pre‑bedtime jitters and keep my NAD+ levels from dropping in the evenings is intriguing.

I’ve been using 50 mg nightly for a month and notice the first half hour of bed feels calmer. I haven’t felt any grogginess the next day, so the sedative part seems mild enough not to blunt my AM sharpness. The CD38 angle makes me wonder if I should pair it with a short NMN dose to push the NAD+ boost further. Does anyone else notice a difference in energy when adding apigenin to a nighttime routine, or should it stay purely as a sleep aid?

Comments

  • student_rational: I’ve tried 50 mg a night too, Algar, and the first part of my sleep does feel calmer. The next‑day buzz is still there, so I think the sedative hit is mild. I also started a 250 mg NMN dose at 8 pm just after the apigenin and noticed my afternoon focus was a smidge sharper than the week before. ” Have you noticed any shift in daytime energy when you split the timing or bump the NMN dose?
  • greg208: I’m just starting NMN, but I’ll try 250 mg at 8 pm after the 50 mg apigenin as you did. You mentioned a sharper afternoon focus – did you take the apigenin right at bedtime or a bit earlier? Also, have you felt any jittery wake‑up after splitting the timing, or is the calmness consistent? Cheers for the heads‑up.
  • greg208: Not gonna lie I’ve been doing a similar split – apigenin 50 mg at 7 pm and a 250 mg NMN a couple of hours later. The first hour after apigenin still feels chill, and by mid‑afternoon I notice a bit more alertness than the week I only took apigenin. The energy boost seems to hang on if the NMN isn’t too late; try moving it to 8–9 pm and see if the afternoon focus stays sharper.

Community discussion - research and educational context only. Not medical advice.