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Why I’m Trying FOXO4‑DRI with a Light Rapamycin Pulse – Thoughts?

Posted by greg208 in Longevity & Anti-Aging - 6 points, 4 comments.

I’ve been on the Immortality Stack for about six weeks now, popping Epithalon and 250mg of NMN daily, SS‑31 in the morning and a 4‑mg dose of Rapamycin on Fridays. I added FOXO4‑DRI 10mg/kg 3× a week for a month to see if senescent‑cell clearance would help my joints and skin. For me, the first couple of weeks the injections felt a bit like a flu shot – mild swellingந and a low‑grade fever around the injection site.

By the third week I noticed my morning stiffness easing, a slightly smoother complexion, and a better sleep cycle. Sleep was still a bit restless, but the quality less fragmented, and I woke up feeling less groggy. My energy in the evenings has improved – I can finish a workout without that post‑exercise crash.

I haven’t hit any major side effects so far, just a bit of minor fatigue after the first FOXO4‑DRI cycle. I’m curious if others have mixed the senolytic with a low‑dose Rapamycin pulse. Does the mTOR inhibition interact with the FOXO4‑p53 disruption?

Any comfort tips for the injection site, or do you recommend a suite of anti‑inflammatory co‑facilitators? I’m still on day two of a six‑week cycle and will keep aMJ log to see if the benefits level out or lift further. Hope this sparks a discussion.

Comments

  • grace_sleepnerd: I’ve had a similar combo with a low‑dose Rap pulse and a senolytic (dasatinib‑quercetin) and the injection site has been my main complaint. I found that mixing a cold compress right after and taking a small dose of fish‑oil or a turmeric მარტly the next day keeps the swelling down. I don’t use any other anti‑inflammatories because the rapamycin pulse already nudges the immune tone. I’ve also noticed that doing the injections in the evening, before bed, seems to let the mild fever surface early
  • greg208: Thanks for the tips. I’ve been doing the FOXO4‑DRI shots in the morning, so the little fever comes up during the day and I can just push it through my usual routine. I haven’t tried a cold compress or fish‑oil yet, but I’ll give it a go next week. Did your evening injections help you sleep better or just feel less soreideos?
  • hank_m: Tbh i inject my FOXO4‑DRI in the evening too, around 9 pm after dinner. The mild fever usually kicks in by midnight and i sleep through it. Have you tried splitting the dose or doing it every other day?
  • greg208: I was doing the injections around mid‑afternoon – the fever kicked in before bed andrao threw off my sleep. Splitting the 10 mg/kg dose into two 5 mg pre‑dose shots on alternate days might tame the fever while keeping the senolytic effect. I’ll give that a go next week. Do you notice any change in fatigue or recovery when you split or shift the timing?

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