ResearchSafe

Numbness after starting MK‑677 – is it normal?

Posted by grace_sleepnerd in Safety & Side Effects - 7 points, 6 comments.

I started MK‑677 25mg a few weeks ago, 10‑15 minutes after breakfast. Right after the first dose I felt a tingling in my fingertips that lingered for a half‑hour. It’s mild, not a sharp ache, more like a subtle electric buzz.

I then kept going and the next day the tingling showed up again in the same spots, a bit stronger after the meal. I’m still on my first month and I didn’t notice any swelling or redness at the injection sites – I only take thecess orally. I’ve read that the “numbness/tingling in hands” side effect is listed for the Superman stack, but I was wondering if that also applies to MK‑677 alone.

D. In pharmacology so I’m lookingMonitoring for the fasting glucose changes, but the tingling is the first odd thing. Anyone else see it, or does it go away with time? I’m not sure if it’s just a placebo feel‑thing or something I should be worried about.

Comments

  • hank_m: Tbh i’ve-measured the same tingling with my own 10 mg daily run, and it faded after a month or so, almost like it was just nervous system adjusting to the IGF‑1 surge, not a bad sign, but keep an eye on it. I haven’t seen any swelling or redness, so i think it’s probably a mild peripheral nerve effect, maybe amplified by the food you’re eating. I’d add that it can help to slow the dose a bit or split it into two smaller doses and see if that reduces the buzz. Any way you’re tracking glucoseakti
  • practicalpaul: I’m glad the tingling faded for you too after a month – that matches what I’ve seen in my own logs. 5 mg doses and the buzz dropped by about 40 %. I’ve been tracking fasting glucose, it stayed around 90–95 mg/dL even as the IGF‑1 peak hit 3500 pg/mL, so no obvious glucose spike. How are your glucose readings looking with the split dose?
  • ivy_mobility: I also felt that buzz at 25 mg, took it with breakfast. After about three weeks it dulled and now barely noticeable. Splitting the dose helped me a bit. Have you seen any changes in fasting glucose or HbA1c yet?
  • grace_sleepnerd: Thanks for the heads‑up. I’ve been checking my fasting glucose and it’s still hovering in the normal range so far. I’ll try splitting the 25 mg into two 12.5‑mg doses like you did – you mentioned it helped dampen the buzz. Did you notice it stay hittar? Also, should I keep an eye on HbA1c now or wait a few more weeks?
  • grace_sleepnerd: 5 mg at lunch. My latest fasting glucose came in at 92 mg/dL, so it’s holding steady. The tingling has dropped about 30 % in the last week. Will keep an eye on the IGF‑1; you mentioned 3500 pg/mL, what’s your baseline before starting?
  • grace_sleepnerd: Sounds about right for my 25 mg dose. I’ll try going back to 10 mg, maybe split into 5 mg twice a day, and see if the buzz eases. I’ve been logging glucose every morning and it’s hovering around 95‑102 mg/dL so far, no spikes. Does anyone else see a pattern with certain meals?

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