AHK-Cu (AHK-Cu (Alanine-Histidine-Lysine Copper Peptide))
A copper-binding tripeptide (Ala-His-Lys) chelated to copper, closely related to GHK-Cu but especially popular for hair growth and follicle support. Widely used topically in biohacker hair and scalp formulations.
How it works
Delivers copper to tissue and signals angiogenesis and growth-factor activity (notably VEGF) around hair follicles, promoting follicle vascularization, prolonging the anagen (growth) phase, and supporting collagen production.
Key facts
- Molecular weight: ~403 Da (with copper)
- Half-life: Topical (local action)
- Bioavailability: Topical (serum/solution); local delivery
- Storage: Cool, dark place; refrigeration extends shelf life of solutions.
Dosing overview
- Typical dose: ~0.5-2 mg/mL topical serum
- Frequency: 1-2x daily on scalp
- Duration: Ongoing
- Route: Topical
Protocol notes
- Applied as a topical scalp serum, typically once or twice daily to clean, dry scalp.
- Frequently combined with GHK-Cu or minoxidil in hair-growth stacks.
- Consistent daily use over months is needed to assess follicle response.
Reported benefits
- Hair follicle support and growth signaling
- Follicle vascularization (VEGF)
- Prolongs anagen growth phase
- Collagen and skin support
- Antioxidant copper delivery
Possible side effects
- Scalp irritation (rare)
- Temporary blue-green staining
- Contact sensitivity (rare)
Research
- AHK-Cu and hair follicle growth (2007): Copper tripeptide AHK-Cu increased hair follicle size and promoted VEGF-driven follicle vascularization in studies.
- Copper peptides and dermal support (2015): Copper-binding peptides supported angiogenesis, collagen synthesis, and skin/scalp remodeling.
Compare AHK-Cu
Research and educational reference only. Not medical advice.