Akkermansia (Akkermansia muciniphila (Pasteurized))
A keystone gut bacterium that resides in the mucus layer and is inversely correlated with obesity, diabetes, and metabolic syndrome. Pasteurized form retains metabolic benefits through its membrane protein Amuc_1100.
How it works
Amuc_1100 outer membrane protein activates TLR2 signaling, strengthening gut barrier and improving metabolic endotoxemia. Stimulates mucin production by goblet cells. Enhances GLP-1 secretion and improves insulin signaling.
Key facts
- Molecular weight: Whole organism (not applicable)
- Half-life: Colonizes mucus layer; effects persist with continued use
- Bioavailability: Oral - pasteurized form survives transit; live form colonizes
- Storage: Room temperature (pasteurized). Live form: refrigerate.
Dosing overview
- Typical dose: 10 billion CFU (pasteurized) or 100mg membrane extract
- Frequency: Daily
- Duration: Ongoing (8-12 weeks minimum for metabolic effects)
- Route: Oral capsule
Reported benefits
- Improved metabolic markers
- Reduced insulin resistance
- Gut barrier strengthening
- Weight management support
- Reduced systemic inflammation
- Enhanced GLP-1 secretion
Possible side effects
- Mild GI adjustment period
- Temporary bloating
- Generally very well-tolerated
Research
- Pasteurized Akkermansia and metabolic syndrome (2022): Improved insulin sensitivity by 30%, reduced LPS endotoxemia, and decreased body weight by 2.3kg over 12 weeks vs placebo.
- Akkermansia and GLP-1 axis (2021): Amuc_1100 protein increased GLP-1 secretion by 2-fold in human enteroendocrine cell models, independent of live bacterial colonization.
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Community discussions about Akkermansia
- Pasteurized Akkermansia – gut barrier boost or hype? - 4 comments
- Ask the community about Akkermansia
Research and educational reference only. Not medical advice.