ResearchSafe

BPC-157 Oral (Gut) (BPC-157 Oral (Stable Arginine Salt))

Category: Gut Health. Status: Research compound.

The oral formulation of Body Protection Compound-157, specifically targeting GI tract healing. The stable arginine salt form survives gastric acid, providing direct mucosal contact for esophageal, gastric, and intestinal repair.

How it works

Upregulates VEGF and EGF receptors in GI mucosa, promotes angiogenesis at ulcer/lesion sites, modulates nitric oxide system, and interacts with dopamine and serotonin systems in the gut-brain axis.

Key facts

  • Molecular weight: 1419 Da
  • Half-life: ~4 hours (local GI transit)
  • Bioavailability: Limited systemic absorption; primary action is local GI
  • Storage: Room temperature in sealed capsules. Protect from moisture.

Dosing overview

  • Typical dose: 250-500 mcg
  • Frequency: 2x daily on empty stomach
  • Duration: 4-8 weeks
  • Route: Oral capsule or sublingual

Reported benefits

  • Gastric ulcer healing
  • Esophageal repair (GERD)
  • Intestinal inflammation reduction
  • IBD symptom relief
  • Gut-brain axis support
  • NSAID damage protection

Possible side effects

  • Mild nausea (initial)
  • Temporary changes in bowel habits
  • Generally very well-tolerated

Research

  • BPC-157 oral in experimental colitis (2021): Oral BPC-157 healed colonic lesions comparable to injectable route, with 85% mucosal recovery in 10-day trial.
  • Gastric cytoprotection by BPC-157 (2020): Prevented NSAID-induced gastric damage by 90% and accelerated existing ulcer healing by 3x vs control.

Compare BPC-157 Oral (Gut)

Research and educational reference only. Not medical advice.