Bufotenin (5-Hydroxy-DMT)

Category: Psychedelics. Status: Schedule I (research compound).

A naturally occurring tryptamine found in some toads, plants and seeds (like yopo snuff). Closely related to DMT and 5-MeO-DMT and used traditionally in snuffs.

How it works

Activates serotonin receptors; has strong peripheral cardiovascular effects in addition to central effects.

Key facts

• Molecular weight: 204.27 g/mol
• Half-life: Short
• Bioavailability: Oral
• Storage: Research/reference only.

Dosing overview

• Typical dose: Varies by individual and setting
• Frequency: Occasional
• Duration: Acute effects short
• Route: Insufflated (snuff) or injected

Protocol notes

• Historically used in snuffs (yopo) made from seeds, blown into the nose.
• Produces strong body effects, so traditional use is always in a supported group setting.

Reported benefits

• Found in traditional snuffs (yopo)
• Closely related to DMT
• Studied in ethnobotany
• Natural tryptamine

Possible side effects

• Strong cardiovascular effects
• Nausea and vomiting
• Facial flushing
• Limited modern safety data

Compare Bufotenin

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Community discussions about Bufotenin

• Bufotenin cardiovascular effects, anyone actually monitored BP and HR during it? - 6 comments
• Heart rate and BP with tryptamines - 0 comments
• Ask the community about Bufotenin

Research and educational reference only. Not medical advice.