Ergothioneine (L-Ergothioneine)
A rare sulfur-containing amino acid derived from mushrooms and certain bacteria, dubbed "the longevity vitamin." The body has a dedicated transporter (OCTN1) that concentrates it in tissues under oxidative stress, and low levels correlate with age-related disease.
How it works
Accumulates via the OCTN1 transporter in mitochondria and other high-stress cellular compartments, where it scavenges reactive oxygen species, chelates metals, protects DNA and mitochondria, and preserves other antioxidants.
Key facts
- Molecular weight: 229.30 Da
- Half-life: Very long (weeks; retained in tissue)
- Bioavailability: Good oral via OCTN1 transporter
- Storage: Room temperature, protect from light.
Dosing overview
- Typical dose: 5-25 mg per day
- Frequency: Once daily
- Duration: Ongoing
- Route: Oral capsule
Protocol notes
- General longevity use: 5-10 mg/day.
- Higher intakes (up to ~25-30 mg/day) have been studied and well tolerated.
- Because it is retained in tissues, daily dosing steadily raises body stores.
Reported benefits
- Potent cellular and mitochondrial antioxidant
- Long tissue retention
- DNA and lipid protection
- Neuroprotective potential
- Associated with lower age-related disease risk
- Anti-inflammatory
Possible side effects
- No established side effects
- Considered very well tolerated
Research
- Ergothioneine as a longevity vitamin (2020): Proposed as a diet-derived compound whose deficiency is linked to increased risk of age-related chronic disease.
- Low ergothioneine predicts cardiovascular risk (2019): Higher plasma ergothioneine was associated with lower cardiovascular and all-cause mortality in a large cohort.
Compare Ergothioneine
Research and educational reference only. Not medical advice.