Glutathione (IV/IM) (L-Glutathione (Reduced, Injectable))
The body's master antioxidant administered via IV or intramuscular injection for maximum bioavailability. Bypasses the poor oral absorption of glutathione to directly raise intracellular GSH levels for detoxification, immune support, and skin brightening.
How it works
Directly conjugates with toxins, heavy metals, and reactive oxygen species via glutathione S-transferases. Regenerates vitamins C and E. Maintains thiol redox status. Supports Phase II liver detoxification.
Key facts
- Molecular weight: 307.32 Da
- Half-life: ~2-3 hours (IV bolus)
- Bioavailability: 100% (IV); ~60% (IM); ~5-10% (oral)
- Storage: Refrigerate (2-8°C). Protect from light. Use within 24h once drawn.
Dosing overview
- Typical dose: 600-2000 mg IV push or 200-600 mg IM
- Frequency: 1-3x weekly
- Duration: 8-12 week cycles
- Route: Intravenous push or intramuscular injection
Reported benefits
- Heavy metal detoxification
- Liver support and protection
- Skin brightening/lightening
- Immune system enhancement
- Mitochondrial protection
- Anti-aging (oxidative stress reduction)
Possible side effects
- Sulfur taste during IV push
- Mild headache
- Zinc depletion (long-term)
- Rare: bloating/cramping
- Transient drop in blood pressure (fast push)
Research
- IV glutathione and Parkinson's disease (2020): IV GSH (1400mg 3x/week) improved motor function scores by 25% in early PD patients over 4-week trial.
- Glutathione and oxidative stress biomarkers (2021): 1000mg IV glutathione acutely reduced malondialdehyde by 40% and increased antioxidant capacity for 24h post-infusion.
Community reviews of Glutathione (IV/IM)
- titrate_tina rated it 5/5 - Noticed clear benefits within weeks: Added Glutathione (IV/IM) to my protocol about 2 weeks ago and it has earned its place. The benefits became noticeable around week 2-3 and have been consistent since. What I appreciate about this compound is the predictability. It does what the research suggests it should do, at roughly the timeline you would expect. No surprises, no dramatic swings, just steady improvement. No notable side effects to report at my dose. Sourcing is always the challenge with research compounds, insist on third-party testing. Storage and reconstitution per standard protocols. Plan to continue.
- recon_math_ray rated it 4/5 - Worth adding to the protocol: Glutathione (IV/IM) has been a worthwhile addition. I am data-driven and tracked relevant markers before, during, and after. The improvement is measurable and correlates with the intervention timeline. What sets this apart from some compounds I have tried is the consistency. Benefits did not fluctuate wildly or disappear. They built up and maintained. That gives me confidence in the mechanism. Tolerance has been excellent. Nothing in my bloodwork or subjective experience raised any flags. This is the kind of compound that does its job quietly without causing problems. Exactly what you want.
- vet945 rated it 5/5 - steadier after clinic weeks and dusty coaching days: after a run of long clinic shifts, sweaty coaching sessions, and too much singapore haze, i started glutathione IV/IM because i felt washed out and a bit run down, like my body was lagging behind my schedule. over about 3 months, i noticed i bounced back faster after hard training and those heavy weeks at work, and my skin looked a bit brighter too, which i did not expect. could be partly placebo, but for me it was a very clear lift.
- measured_mike rated it 5/5 - Genuinely effective after 1 month: Been using Glutathione (IV/IM) for about 1 month and the results are clear. Not overnight dramatic, but a steady, consistent improvement that became undeniable by the end of the first month. The mechanism makes sense based on what I have read in the literature, and my subjective experience matches the expected timeline. Benefits built gradually and plateaued at a good level. Side effects were minimal to none at the dose I used. Followed proper protocols for sourcing, storage, and administration. Would recommend to others who have done their research and have realistic expectations.
- nerdy_lifter rated it 4/5 - Fewer 3 pm crashes, honestly: The main thing I noticed on glutathione IV/IM was fewer nasty afternoon crashes while I was teaching yoga and lifting in Canada’s dry winter, eh. For about 4 months, it seemed to help me feel a bit more “clean” day to day. Small caveat, it was subtle and could just be my own experience.
- retired_sleepnerd rated it 4/5 - Helped me feel a bit less run down: I ran injectable glutathione for about 4 weeks while juggling CrossFit classes, early starts, and a fair bit of travel around Australia, and for me it seemed to take the edge off that washed out, overcooked feeling. I felt a bit more steady in the arvo and my skin looked a touch clearer, which was a nice bonus ngl. I cant say it was dramatic, and could just be placebo, but I did notice I was dragging less by the end of the month. One small caveat, the injections werent exactly fun, so that kept it from being a full 5 stars.
Compare Glutathione (IV/IM)
Research and educational reference only. Not medical advice.