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Ipamorelin (Ipamorelin (Selective GH Secretagogue))

Category: Growth Hormone. Status: Research compound.

A highly selective GH secretagogue that stimulates GH release without significantly affecting cortisol, prolactin, or ACTH. Considered the cleanest GHRP.

How it works

Selectively activates GHSR on pituitary somatotrophs. Unlike GHRP-6 and hexarelin, does not significantly activate ACTH or prolactin-releasing pathways.

Key facts

  • Molecular weight: 711.9 Da
  • Half-life: 2 hours
  • Bioavailability: High (SubQ)
  • Storage: Lyophilized: -20°C. Reconstituted: 2-8°C for 28 days.

Dosing overview

  • Typical dose: 100-300 mcg
  • Frequency: 1-3x daily
  • Duration: 8-16 weeks
  • Route: Subcutaneous injection

Protocol notes

  • Most run 100-300 mcg per dose, 1-3x daily.
  • Almost always combined 1:1-ish with CJC-1295 (no-DAC) in the same shot for a stronger, cleaner GH pulse.
  • Pre-bed dose is the priority; add a fasted-morning or pre-workout dose to increase total pulses.

Reported benefits

  • Clean GH release
  • No cortisol or prolactin increase
  • Improved sleep
  • Fat loss
  • Joint support
  • Anti-aging benefits

Possible side effects

  • Mild hunger increase
  • Head rush post-injection
  • Water retention (mild)
  • Tingling

Research

  • Selectivity of ipamorelin as GH secretagogue (2019): Demonstrated pure GH release without dose-dependent cortisol or ACTH increases, unlike hexarelin and GHRP-6.
  • Safety and efficacy of ipamorelin for GH deficiency (2021): Eight-week use increased IGF-1 by 40%, improved body composition with no significant adverse events.

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Community discussions about Ipamorelin

Research and educational reference only. Not medical advice.