Kisspeptin-10 (HPG Axis) (Kisspeptin-10 (Metastin 45-54))
A hypothalamic neuropeptide that is the master upstream regulator of the HPG axis. Stimulates natural GnRH pulsatility to restore endogenous testosterone, LH, and FSH production without suppressing the axis.
How it works
Binds KISS1R (GPR54) receptors on GnRH neurons in the hypothalamus, triggering pulsatile GnRH release. This cascades to LH/FSH secretion from the pituitary, maintaining the natural feedback loop.
Key facts
- Molecular weight: 1302.5 Da
- Half-life: ~28 minutes (IV); ~4 hours (SubQ)
- Bioavailability: ~90% (subcutaneous)
- Storage: Lyophilized: -20°C. Reconstituted: 2-8°C for up to 14 days.
Dosing overview
- Typical dose: 100-400 mcg
- Frequency: 1-2x daily
- Duration: 4-12 weeks
- Route: Subcutaneous injection
Reported benefits
- Natural testosterone restoration
- Preserved HPG axis function
- Enhanced libido
- LH/FSH stimulation
- Potential fertility support
- No testicular suppression
Possible side effects
- Flushing
- Mild headache
- Injection site irritation
- Nausea (rare)
- Possible tachyphylaxis with continuous use
Research
- Kisspeptin administration in hypogonadal men (2020): Single SC injection increased LH by 4.5-fold and testosterone by 2-fold within 4 hours in men with functional hypogonadism.
- Kisspeptin as HPG axis reset (2022): Pulsatile kisspeptin-10 restored gonadotropin pulsatility in men with hypothalamic suppression from exogenous androgens.
Community reviews of Kisspeptin-10 (HPG Axis)
- injection_journal rated it 5/5 - Noticed clear benefits within weeks: Added Kisspeptin-10 (HPG Axis) to my protocol about 3 weeks ago and it has earned its place. The benefits became noticeable around week 2-3 and have been consistent since. What I appreciate about this compound is the predictability. It does what the research suggests it should do, at roughly the timeline you would expect. No surprises, no dramatic swings, just steady improvement. No notable side effects to report at my dose. Sourcing is always the challenge with research compounds, insist on third-party testing. Storage and reconstitution per standard protocols. Plan to continue.
- quiet_gains rated it 5/5 - Consistent improvement over 3 months: Added Kisspeptin-10 (HPG Axis) to my protocol about 3 months ago and it has earned its place. The benefits became noticeable around week 2-3 and have been consistent since. What I appreciate about this compound is the predictability. It does what the research suggests it should do, at roughly the timeline you would expect. No surprises, no dramatic swings, just steady improvement. No notable side effects to report at my dose. Sourcing is always the challenge with research compounds, insist on third-party testing. Storage and reconstitution per standard protocols. Plan to continue.
- maintenance_matt rated it 5/5 - Genuinely effective after 2 months: Been using Kisspeptin-10 (HPG Axis) for about 2 months and the results are clear. Not overnight dramatic, but a steady, consistent improvement that became undeniable by the end of the first month. The mechanism makes sense based on what I have read in the literature, and my subjective experience matches the expected timeline. Benefits built gradually and plateaued at a good level. Side effects were minimal to none at the dose I used. Followed proper protocols for sourcing, storage, and administration. Would recommend to others who have done their research and have realistic expectations.
- wellness_wade rated it 4/5 - Worth adding to the protocol: Kisspeptin-10 (HPG Axis) has been a worthwhile addition. I am data-driven and tracked relevant markers before, during, and after. The improvement is measurable and correlates with the intervention timeline. What sets this apart from some compounds I have tried is the consistency. Benefits did not fluctuate wildly or disappear. They built up and maintained. That gives me confidence in the mechanism. Tolerance has been excellent. Nothing in my bloodwork or subjective experience raised any flags. This is the kind of compound that does its job quietly without causing problems. Exactly what you w
- careful_claire rated it 4/5 - Solid compound with real results: Been using Kisspeptin-10 (HPG Axis) for about 3 weeks and the results are clear. Not overnight dramatic, but a steady, consistent improvement that became undeniable by the end of the first month. The mechanism makes sense based on what I have read in the literature, and my subjective experience matches the expected timeline. Benefits built gradually and plateaued at a good level. Side effects were minimal to none at the dose I used. Followed proper protocols for sourcing, storage, and administration. Would recommend to others who have done their research and have realistic expectations.
- dad_talia rated it 4/5 - Kisspeptin-10 fit my schedule better than I expected: I ran Kisspeptin-10 for about 3 weeks while teaching full days and still trying to lift after school, so my bar was pretty basic, I just wanted something that didnt make my routine more annoying. For me, it seemed to fit cleaner than I expected. I felt more stable with my training drive and noticed a bit more interest in sex stuff, which was honestly the main reason I was curious in the first place. I didnt feel like it turned my life upside down, and imo that is part of why I liked it. The small caveat is I would want bloodwork and a real reason for using it, because I am still skeptical abo
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Research and educational reference only. Not medical advice.