Kisspeptin-10 (HPG Axis) (Kisspeptin-10 (Metastin 45-54))
A hypothalamic neuropeptide that is the master upstream regulator of the HPG axis. Stimulates natural GnRH pulsatility to restore endogenous testosterone, LH, and FSH production without suppressing the axis.
How it works
Binds KISS1R (GPR54) receptors on GnRH neurons in the hypothalamus, triggering pulsatile GnRH release. This cascades to LH/FSH secretion from the pituitary, maintaining the natural feedback loop.
Key facts
- Molecular weight: 1302.5 Da
- Half-life: ~28 minutes (IV); ~4 hours (SubQ)
- Bioavailability: ~90% (subcutaneous)
- Storage: Lyophilized: -20°C. Reconstituted: 2-8°C for up to 14 days.
Dosing overview
- Typical dose: 100-400 mcg
- Frequency: 1-2x daily
- Duration: 4-12 weeks
- Route: Subcutaneous injection
Reported benefits
- Natural testosterone restoration
- Preserved HPG axis function
- Enhanced libido
- LH/FSH stimulation
- Potential fertility support
- No testicular suppression
Possible side effects
- Flushing
- Mild headache
- Injection site irritation
- Nausea (rare)
- Possible tachyphylaxis with continuous use
Research
- Kisspeptin administration in hypogonadal men (2020): Single SC injection increased LH by 4.5-fold and testosterone by 2-fold within 4 hours in men with functional hypogonadism.
- Kisspeptin as HPG axis reset (2022): Pulsatile kisspeptin-10 restored gonadotropin pulsatility in men with hypothalamic suppression from exogenous androgens.
Compare Kisspeptin-10 (HPG Axis)
Research and educational reference only. Not medical advice.