Leuphasyl (Leuphasyl (Pentapeptide-18))

Category: Skin & Anti-Aging. Status: Research compound.

A pentapeptide mimicking enkephalin that binds enkephalin receptors on nerve cells, reducing neural excitability and complementing argireline for enhanced anti-wrinkle effects.

How it works

Binds enkephalin receptors on neuronal membranes, reducing calcium influx and neurotransmitter release at the presynaptic level. Works upstream of argireline.

Key facts

• Molecular weight: 599.7 Da
• Half-life: 6-10 hours (topical)
• Bioavailability: Moderate (topical)
• Storage: Room temperature, away from light.

Dosing overview

• Typical dose: 3-5% solution
• Frequency: 2x daily
• Duration: 4-8 weeks
• Route: Topical

Reported benefits

• Complements argireline action
• Reduces muscle tension
• Smooths expression lines
• Gentle mechanism

Possible side effects

• Minimal side effects
• Rare tingling

Research

• Synergistic anti-wrinkle effects of leuphasyl and argireline (2020): 5% leuphasyl + 10% argireline reduced wrinkle depth by 47% vs 30% for argireline alone.
• Enkephalin-mimetic peptides for cosmetic neuromodulation (2019): Reduced nerve cell excitability by 35% through enkephalin receptor binding.

Compare Leuphasyl

• Leuphasyl vs Copper Peptides
• Leuphasyl vs Matrixyl
• Leuphasyl vs Argireline
• Leuphasyl vs SNAP-8
• Leuphasyl vs Palmitoyl Tripeptide-1
• Leuphasyl vs Palmitoyl Tetrapeptide-7

Community discussions about Leuphasyl

• Trying Leuphasyl topically for fine lines – any experience? - 4 comments
• Leuphasyl and Argireline: A Real‑World Test for Wrinkle प्रसिद्ध - 4 comments
• Trying Leuphasyl topical for smoother forehead lines – my 4 week log - 9 comments
• Ask the community about Leuphasyl

Research and educational reference only. Not medical advice.