Methyltestosterone (Methyltestosterone (Oral Testosterone))
One of the first orally active androgens, a 17aa form of testosterone used historically for hypogonadism and delayed puberty. Largely superseded by safer TRT options due to liver toxicity. Educational reference only.
How it works
A 17-alpha-alkylated testosterone that survives first-pass liver metabolism, allowing oral dosing. It acts on androgen receptors like testosterone and aromatizes to estrogen, but its 17aa structure makes it hepatotoxic.
Key facts
- Molecular weight: 302.5 Da
- Half-life: ~2.5-4 hours
- Bioavailability: Oral (17aa)
- Storage: Room temperature; keep dry.
Dosing overview
- Typical dose: Medical: ~10-50 mg/day (historical)
- Frequency: Daily
- Duration: Short courses
- Route: Oral or buccal tablet
Protocol notes
- Historically dosed for hypogonadism and delayed puberty.
- Largely replaced by injectable/transdermal TRT due to liver toxicity.
- Included for educational completeness.
Reported benefits
- Oral testosterone activity
- Treats androgen deficiency (historical)
- Convenience of oral dosing
Possible side effects
- Liver toxicity
- Estrogenic effects
- Adverse lipids
- Testosterone suppression
- Largely obsolete
Research
- Oral methyltestosterone limitations (2013): Effective orally but limited by hepatotoxicity, prompting a shift to non-17aa TRT formulations.
Compare Methyltestosterone
Research and educational reference only. Not medical advice.