Methyltestosterone (Methyltestosterone (Oral Testosterone))
One of the first orally active androgens, a 17aa form of testosterone used historically for hypogonadism and delayed puberty. Largely superseded by safer TRT options due to liver toxicity. Educational reference only.
How it works
A 17-alpha-alkylated testosterone that survives first-pass liver metabolism, allowing oral dosing. It acts on androgen receptors like testosterone and aromatizes to estrogen, but its 17aa structure makes it hepatotoxic.
Key facts
- Molecular weight: 302.5 Da
- Half-life: ~2.5-4 hours
- Bioavailability: Oral (17aa)
- Storage: Room temperature; keep dry.
Dosing overview
- Typical dose: Medical: ~10-50 mg/day (historical)
- Frequency: Daily
- Duration: Short courses
- Route: Oral or buccal tablet
Protocol notes
- Historically dosed for hypogonadism and delayed puberty.
- Largely replaced by injectable/transdermal TRT due to liver toxicity.
- Included for educational completeness.
Reported benefits
- Oral testosterone activity
- Treats androgen deficiency (historical)
- Convenience of oral dosing
Possible side effects
- Liver toxicity
- Estrogenic effects
- Adverse lipids
- Testosterone suppression
- Largely obsolete
Research
- Oral methyltestosterone limitations (2013): Effective orally but limited by hepatotoxicity, prompting a shift to non-17aa TRT formulations.
Community reviews of Methyltestosterone
- protocol_pete rated it 5/5 - Solid gains with manageable sides: Ran Methyltestosterone for about 2 months at a moderate dose with proper support (AI, liver support, PCT planned). Strength went up noticeably by week 3-4 and body composition improved steadily. Side effects were present but manageable at the dose I ran. Some acne on shoulders, slight mood elevation (positive), and lipids shifted but stayed within an acceptable range per bloodwork. Did not push the dose and I think that made the difference. This is not something to approach without bloodwork, proper cycle support, and a real PCT plan. But used responsibly, the results are undeniable. Recover
- compound_curious rated it 5/5 - Results matched expectations at moderate dose: Moderate dose of Methyltestosterone for 1 month. Added about 8-12 lbs of lean tissue while body fat stayed stable or dropped slightly. Strength gains were progressive and consistent. Bloodwork at mid-cycle showed suppressed natural production as expected, lipids shifted but not dramatically. Liver values stayed fine. Ran proper cycle support throughout. The compound does what it says. It is not magic and it does not replace hard training and diet, but it amplifies everything you are already doing correctly. PCT brought things back to baseline within 4-6 weeks.
- bloodwork_brett rated it 4/5 - Recovery and strength both improved: Ran Methyltestosterone for about 6 weeks at a moderate dose with proper support (AI, liver support, PCT planned). Strength went up noticeably by week 3-4 and body composition improved steadily. Side effects were present but manageable at the dose I ran. Some acne on shoulders, slight mood elevation (positive), and lipids shifted but stayed within an acceptable range per bloodwork. Did not push the dose and I think that made the difference. This is not something to approach without bloodwork, proper cycle support, and a real PCT plan. But used responsibly, the results are undeniable. Recovery
- loading_phase_lucy rated it 5/5 - Bloodwork stayed reasonable throughout: Methyltestosterone delivered on its reputation. Used at a conservative dose because I value health markers over maximum gains. Still got impressive results: strength up across all lifts, muscle fullness noticeably improved, recovery between sessions dramatically better. Side effect management was key. Had my protocols dialed in before starting. Minor androgenic sides (slightly oily skin) that resolved post-cycle. No significant mood issues at my dose. Would I run again? Yes, but with the same conservative approach and mandatory bloodwork. These compounds demand respect and responsibility.
Compare Methyltestosterone
Research and educational reference only. Not medical advice.