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NAD+ (Nicotinamide Adenine Dinucleotide (NAD+ / NMN / NR))

Category: Anti-Aging. Status: Research compound.

Critical coenzyme declining 50% between ages 40-60. Supplementation via precursors (NMN, NR) or direct NAD+ infusion restores cellular energy, DNA repair, and sirtuin pathways.

How it works

NAD+ serves as cofactor for sirtuins (SIRT1-7), PARPs (DNA repair), and CD38. Declining NAD+ impairs mitochondrial function and epigenetic maintenance. Restoration reactivates longevity pathways.

Key facts

  • Molecular weight: 663.4 Da
  • Half-life: 1-4 hours (IV), 4-8h (oral precursors)
  • Bioavailability: 100% (IV), variable (oral 5-30%)
  • Storage: NMN/NR: cool, dry, sealed. NAD+ solution: refrigerated.

Dosing overview

  • Typical dose: 250-500mg IV or 500-1000mg NMN oral
  • Frequency: Weekly (IV) or Daily (oral)
  • Duration: Ongoing
  • Route: IV infusion or Oral (precursors)

Reported benefits

  • Restored cellular energy
  • Enhanced DNA repair
  • Sirtuin activation
  • Improved mitochondrial function
  • Cognitive clarity
  • Anti-aging

Possible side effects

  • Flushing (IV)
  • Nausea
  • Headache
  • Insomnia if taken late
  • GI discomfort (oral)

Research

  • NAD+ repletion improves mitochondrial function in aging (2022): Restored mitochondrial membrane potential and ATP production to youthful levels in aged tissue.
  • NMN supplementation RCT in middle-aged adults (2023): 250mg NMN daily for 12 weeks increased blood NAD+ by 40% and improved muscle insulin sensitivity.

Compare NAD+

Research and educational reference only. Not medical advice.