Palmitoyl Pentapeptide-4 (Palmitoyl Pentapeptide-4 (Matrixyl Original))
The original Matrixyl peptide that stimulates collagen production through matrikine signaling. Widely used in anti-aging skincare formulations worldwide.
How it works
Mimics collagen breakdown products (matrikines) that signal fibroblasts to produce new collagen matrix components including types I, III, and IV collagen.
Key facts
- Molecular weight: 802.05 Da
- Half-life: N/A (topical depot effect)
- Bioavailability: Topical: ~8-12% penetration
- Storage: Room temperature, protect from direct sunlight.
Dosing overview
- Typical dose: 2-8% in formulation
- Frequency: 2x daily
- Duration: 8-16 weeks
- Route: Topical serum or cream
Protocol notes
- Used as a leave-on serum or cream containing ~2-8% of the peptide, applied to clean skin.
- Apply morning and night; pat a few drops over the face/neck and follow with moisturizer.
- Visible collagen/wrinkle benefits typically take 8-16 weeks of consistent use.
Reported benefits
- Proven collagen stimulation
- Wrinkle depth reduction
- Improved skin firmness
- Well-tolerated
Possible side effects
- Mild tingling
- Rare sensitivity reaction
Research
- Palmitoyl pentapeptide clinical efficacy (2017): Reduced wrinkle depth by 36% and improved skin thickness by 12% over 16 weeks.
- Matrikine peptides in dermal remodeling (2019): Stimulated collagen I synthesis by 117% and hyaluronic acid by 200% in fibroblast assays.
Compare Palmitoyl Pentapeptide-4
Community discussions about Palmitoyl Pentapeptide-4
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- Ask the community about Palmitoyl Pentapeptide-4
Research and educational reference only. Not medical advice.