PTD-DBM (PTD-DBM (Wnt Pathway Hair Peptide))
A cell-penetrating peptide researched for hair regeneration by activating the Wnt/beta-catenin pathway. It became popular in biohacker hair protocols after studies paired it with valproic acid to induce new follicle formation.
How it works
PTD-DBM disrupts the interaction between CXXC5 and Dishevelled, releasing a natural brake on the Wnt/beta-catenin signaling pathway. Enhanced Wnt signaling promotes hair follicle neogenesis and regeneration.
Key facts
- Molecular weight: ~ (short cell-penetrating peptide)
- Half-life: Topical (local action)
- Bioavailability: Topical (local delivery)
- Storage: Refrigerate reconstituted solution; keep lyophilized cool and dry.
Dosing overview
- Typical dose: Topical scalp application (research)
- Frequency: Daily
- Duration: Ongoing (research)
- Route: Topical
Protocol notes
- Applied topically to the scalp, often reconstituted in a suitable carrier solution.
- Frequently paired with valproic acid, which also activates Wnt signaling, in research protocols.
- Consistent daily use over months is used to assess follicle regeneration.
Reported benefits
- Activates Wnt/beta-catenin hair pathway
- Promotes follicle neogenesis (research)
- Synergy with valproic acid
- Non-hormonal hair mechanism
Possible side effects
- Scalp irritation (possible)
- Unknown long-term human safety
- No approved human products
Research
- PTD-DBM induces hair follicle neogenesis (2017): Topical PTD-DBM with valproic acid activated Wnt/beta-catenin signaling and induced new hair follicle formation in animal models.
Compare PTD-DBM
Research and educational reference only. Not medical advice.