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Silk Peptides (Hydrolyzed Silk Fibroin Peptides)

Category: Skin & Anti-Aging. Status: Research compound.

Bioactive peptides from silk fibroin (Bombyx mori). Rich in glycine, alanine, and serine, they form moisture-retaining films while providing amino acid building blocks.

How it works

Form hydrogen-bonded films on skin for moisture retention. Absorbed peptides provide substrates for keratin/collagen synthesis. Exhibit antioxidant and tyrosinase-inhibiting activity.

Key facts

  • Molecular weight: 500-2,000 Da
  • Half-life: 3-5 hours
  • Bioavailability: Moderate (topical/oral)
  • Storage: Room temperature, protect from humidity.

Dosing overview

  • Typical dose: 1-5% topical or 2-5g oral
  • Frequency: Daily
  • Duration: 8-12 weeks
  • Route: Topical or Oral

Reported benefits

  • Intense hydration
  • Moisture barrier support
  • Skin smoothing
  • Antioxidant activity
  • Brightening effects

Possible side effects

  • Well tolerated
  • Silk allergy possible (rare)

Research

  • Silk fibroin peptides for skin hydration (2022): Increased hydration by 45% and decreased trans-epidermal water loss by 30% after 4 weeks.
  • Antioxidant and brightening effects of silk peptides (2021): Inhibited tyrosinase by 40% and reduced ROS by 55% in UV-exposed keratinocytes.

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Research and educational reference only. Not medical advice.