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SNAP-8 (SNAP-8 (Acetyl Octapeptide-3))

Category: Skin & Anti-Aging. Status: Research compound.

An elongated version of argireline (8 vs 6 amino acids) providing enhanced SNARE complex inhibition for superior wrinkle reduction.

How it works

More effectively competes with SNAP-25 for SNARE complex incorporation due to longer sequence, providing greater vesicle-membrane fusion inhibition.

Key facts

  • Molecular weight: 1,075 Da
  • Half-life: 8-14 hours (topical)
  • Bioavailability: Moderate (topical)
  • Storage: Room temperature, protect from UV.

Dosing overview

  • Typical dose: 3-10% solution
  • Frequency: 2x daily
  • Duration: 4-8 weeks
  • Route: Topical

Reported benefits

  • Superior to argireline
  • Deeper wrinkle reduction
  • Prevents expression lines
  • Good skin penetration

Possible side effects

  • Minimal side effects
  • Rare irritation on sensitive skin

Research

  • Comparative efficacy of octapeptide-3 vs hexapeptide-8 (2021): SNAP-8 at 3% reduced wrinkle depth by 35% vs 27% for argireline at 10% after 28 days.
  • Extended SNARE-inhibiting peptides for anti-aging (2020): Additional residues improved SNARE competition by 60% over hexapeptide variants.

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Research and educational reference only. Not medical advice.