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Somatropin (HGH) (Recombinant Human Growth Hormone)

Category: Growth Hormone. Status: Prescription medication.

Biosynthetic human growth hormone identical to the 191-amino-acid pituitary-derived hormone. Stimulates linear growth, protein synthesis, lipolysis, and organ growth. Widely used in anti-aging, body composition, and recovery research.

How it works

Binds to GH receptors on target cells, triggering the JAK2/STAT5 signaling pathway. Stimulates hepatic IGF-1 production, promotes protein synthesis, mobilizes fatty acids from adipose tissue, and increases glucose output.

Key facts

  • Molecular weight: 22,124 Da
  • Half-life: 2-3 hours (subcutaneous); tissue effects persist 9-17 hours via IGF-1
  • Bioavailability: ~80% subcutaneous
  • Storage: Refrigerated at 2-8C. Do not freeze. Reconstituted vials use within 14-21 days.

Dosing overview

  • Typical dose: 1-4 IU/day (anti-aging/wellness); 4-8 IU/day (performance)
  • Frequency: Daily (split AM/PM for higher doses)
  • Duration: 3-6 months minimum for full benefits
  • Route: Subcutaneous injection

Protocol notes

  • Anti-aging: 1-2 IU daily, AM injection on empty stomach.
  • Body composition: 2-4 IU daily, split AM and post-workout or pre-bed.
  • Performance: 4-8 IU split into 2-3 injections daily.
  • Start low and titrate up over 2-4 weeks to minimize side effects.

Reported benefits

  • Fat loss (especially visceral)
  • Increased lean muscle mass
  • Improved sleep quality
  • Faster recovery from injury
  • Improved skin elasticity
  • Increased bone density
  • Enhanced cognitive function

Possible side effects

  • Water retention and joint pain
  • Carpal tunnel syndrome
  • Insulin resistance
  • Potential for acromegaly features at high doses
  • Numbness/tingling in extremities

Research

  • Effects of GH on body composition in adults (2009): Meta-analysis showed GH therapy reduced body fat by 2.6 kg and increased lean mass by 2.1 kg over 6-12 months.
  • GH replacement and cardiovascular risk (2012): 10-year follow-up showed GH replacement improved lipid profiles and reduced cardiovascular mortality in GH-deficient adults.
  • Growth hormone and aging (2019): Low-dose GH in elderly subjects improved body composition, bone density, and quality of life markers over 2 years.

Compare Somatropin (HGH)

Research and educational reference only. Not medical advice.