TB-500 (Thymosin Beta-4 (Synthetic))
A synthetic version of thymosin beta-4, a naturally occurring 43-amino acid peptide that promotes cell migration, blood vessel growth, and reduces inflammation. Widely researched for tissue repair and regeneration.
How it works
Upregulates actin production to promote cell migration and proliferation, enhances angiogenesis, and reduces pro-inflammatory cytokines.
Key facts
- Molecular weight: 4921 Da
- Half-life: ~6 hours
- Bioavailability: ~95% via subcutaneous injection
- Storage: Lyophilized: -20°C long term. Reconstituted: 2-8°C for up to 14 days.
Dosing overview
- Typical dose: 2-5 mg per dose
- Frequency: Loading: 2x/week · Maintenance: 1x/week
- Duration: 4-8 week loading, then maintenance
- Route: Subcutaneous injection
Protocol notes
- Loading phase: ~2-5 mg twice weekly for 4-6 weeks to build tissue levels.
- Maintenance phase: 2-5 mg once weekly (or every other week) to hold results.
- Frequently stacked with BPC-157 for synergistic soft-tissue recovery.
Reported benefits
- Enhanced wound healing
- Reduced inflammation
- Improved flexibility
- Cardiac tissue repair
- Hair regrowth support
Possible side effects
- Headache
- Injection site redness
- Temporary lethargy
- Head rush
Research
- Thymosin beta-4 promotes angiogenesis and wound healing (2020): Accelerated dermal wound closure and improved vascularization in animal models.
- TB-500 effects on cardiac repair post-MI (2018): Reduced infarct size and improved cardiac function following myocardial infarction in mice.
Compare TB-500
Community discussions about TB-500
- Feedback on adding CJC-1295 DAC to KLOW stack for ultra recovery – timing and safety? - 4 comments
- lifetime surgical piece on bpc vs tb500 post op thoughts - 5 comments
- TB-500 dosing around physio for a strained hamstring – howzit timing? - 7 comments
- "Looking at a low‑dose GHK‑Cu + BPC‑157 + TB‑500 stack – thoughts on timing and evidence?" - 5 comments
- BPC-157 and TB-500 for Achilles flare, timing question - 4 comments
- Ask the community about TB-500
Research and educational reference only. Not medical advice.