Vitamin D3 Injection (Cholecalciferol (Vitamin D3) Injectable)
High-dose injectable vitamin D3 for rapid repletion of deficiency. Telemedicine clinics prescribe it for immune optimization, bone health, and hormone support. Injectable form is ideal for malabsorption patients.
How it works
Converts to 25-hydroxyvitamin D then to active 1,25-dihydroxyvitamin D. Modulates over 200 genes including those for immune function, calcium absorption, bone remodeling, and hormone production.
Key facts
- Molecular weight: 384.64 Da
- Half-life: ~15 days (storage form)
- Bioavailability: ~100% IM
- Storage: Room temperature, protect from light.
Dosing overview
- Typical dose: 50,000-100,000 IU
- Frequency: Weekly to monthly
- Duration: Until optimal levels achieved
- Route: Intramuscular injection
Protocol notes
- For correcting deficiency, a high-dose IM bolus (50,000-100,000 IU) is given weekly or monthly until levels normalize.
- After repletion, most switch to a maintenance schedule (less frequent injections or daily oral D3).
- Co-supplementing vitamin K2 and magnesium is common to direct calcium appropriately.
Reported benefits
- Rapid deficiency correction
- Immune system optimization
- Bone health
- Hormone support
- Mood improvement
- Reduced inflammation
Possible side effects
- Injection site pain
- Hypercalcemia (overdose)
- Nausea
- Kidney stones (rare)
Research
- IM vitamin D3 vs oral supplementation (2021): Single IM injection of 100,000 IU achieved therapeutic levels 3x faster than daily oral supplementation in deficient patients.
Compare Vitamin D3 Injection
Research and educational reference only. Not medical advice.