5-MeO-DMT vs Bufotenin
A side-by-side research comparison of 5-MeO-DMT and Bufotenin across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | 5-MeO-DMT | Bufotenin |
|---|---|---|
| Full name | 5-Methoxy-N,N-dimethyltryptamine | 5-Hydroxy-DMT |
| Category | Psychedelics | Psychedelics |
| Status | Schedule I (research compound) | Schedule I (research compound) |
| Mechanism | Strongly activates serotonin 5-HT1A and 5-HT2A receptors, producing rapid and intense changes in consciousness. | Activates serotonin receptors; has strong peripheral cardiovascular effects in addition to central effects. |
| Molecular weight | 218.30 g/mol | 204.27 g/mol |
| Half-life | Short (minutes) | Short |
| Bioavailability | Inhaled/injected | Oral |
| Typical dose | Low milligram range in clinical studies | Varies by individual and setting |
| Frequency | One to a few supervised sessions | Occasional |
| Route | Inhalation or injection in research settings | Insufflated (snuff) or injected |
5-MeO-DMT reported benefits
- Studied for treatment-resistant depression
- Short duration suits clinical use
- Explored for anxiety
- Rapid onset of effects
Bufotenin reported benefits
- Found in traditional snuffs (yopo)
- Closely related to DMT
- Studied in ethnobotany
- Natural tryptamine
Related comparisons
Research and educational reference only. Not medical advice.