Anastrozole vs Pregnenolone
A side-by-side research comparison of Anastrozole and Pregnenolone across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Anastrozole | Pregnenolone |
|---|---|---|
| Full name | Anastrozole (Arimidex) | Pregnenolone (Mother Hormone) |
| Category | Hormone Replacement | Hormone Replacement |
| Status | FDA-approved prescription | OTC supplement / Prescribed |
| Mechanism | Selectively and reversibly inhibits aromatase (CYP19A1), the enzyme that converts androgens to estrogens. Reduces circulating estradiol levels without affecting other steroid pathways. | Acts as the primary substrate for steroidogenesis (cortisol, DHEA, progesterone, testosterone, estrogen). Also functions as a neurosteroid, enhancing memory and NMDA receptor activity. |
| Molecular weight | 293.37 Da | 316.48 Da |
| Half-life | ~46.8 hours | ~1-3 hours (oral) |
| Bioavailability | ~80-85% oral | ~60% oral |
| Typical dose | 0.25-0.5 mg | 50-100 mg |
| Frequency | 2-3x per week | Daily (morning) |
| Route | Oral tablet | Oral capsule or sublingual |
Anastrozole reported benefits
- Estrogen control
- Reduced water retention
- Prevention of gynecomastia
- Maintained testosterone ratio
- Improved body composition
Pregnenolone reported benefits
- Hormone precursor balance
- Memory enhancement
- Mood improvement
- Joint support
- Myelin sheath repair
- Stress resilience
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Research and educational reference only. Not medical advice.