Anastrozole vs DHEA
A side-by-side research comparison of Anastrozole and DHEA across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Anastrozole | DHEA |
|---|---|---|
| Full name | Anastrozole (Arimidex) | Dehydroepiandrosterone |
| Category | Hormone Replacement | Hormone Replacement |
| Status | FDA-approved prescription | OTC supplement / Prescribed |
| Mechanism | Selectively and reversibly inhibits aromatase (CYP19A1), the enzyme that converts androgens to estrogens. Reduces circulating estradiol levels without affecting other steroid pathways. | Serves as a precursor to both testosterone and estrogen. Also acts directly on DHEA-specific receptors, supports immune function, neurosteroid activity, and cellular metabolism. |
| Molecular weight | 293.37 Da | 288.42 Da |
| Half-life | ~46.8 hours | 15-38 hours |
| Bioavailability | ~80-85% oral | ~100% oral |
| Typical dose | 0.25-0.5 mg | 25-100 mg |
| Frequency | 2-3x per week | Daily (morning) |
| Route | Oral tablet | Oral capsule or topical cream |
Anastrozole reported benefits
- Estrogen control
- Reduced water retention
- Prevention of gynecomastia
- Maintained testosterone ratio
- Improved body composition
DHEA reported benefits
- Hormone precursor support
- Improved energy levels
- Bone density support
- Cognitive function
- Immune enhancement
- Anti-aging
Related comparisons
Research and educational reference only. Not medical advice.