Dihexa vs N-Acetyl Selank Amidate
A side-by-side research comparison of Dihexa and N-Acetyl Selank Amidate across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Dihexa | N-Acetyl Selank Amidate |
|---|---|---|
| Full name | Dihexa (N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide) | N-Acetyl Selank Amidate (NA Selank) |
| Category | Cognitive & Nootropic | Cognitive & Nootropic |
| Status | Research compound | Research compound |
| Mechanism | Allosteric potentiator of HGF/c-Met signaling driving synaptogenesis, dendritic spine formation, and neuronal survival in hippocampal circuits. | Modulates GABA and serotonin systems and influences BDNF and the expression of enkephalin-degrading enzymes, producing anti-anxiety and mood-stabilizing effects. The acetyl/amidate modifications extend its duration. |
| Molecular weight | 507.6 Da | ~800 Da |
| Half-life | 6-12 hours | Longer than base Selank |
| Bioavailability | Moderate (oral/SubQ) | Intranasal (primary); subcutaneous also used |
| Typical dose | 10-20 mg (oral) or 2-5 mg (SubQ) | ~300-900 mcg per day |
| Frequency | Daily | 1-2x daily |
| Route | Oral or Subcutaneous | Intranasal spray/drops |
Dihexa reported benefits
- Dramatic synaptogenesis
- Memory improvement
- Cognitive restoration potential
- Dendritic spine growth
- HGF/c-Met activation
N-Acetyl Selank Amidate reported benefits
- Reduces anxiety without sedation
- Calm focus
- Mood support
- No reported dependence/withdrawal
Related comparisons
Research and educational reference only. Not medical advice.