ResearchSafe

Dihexa (Dihexa (N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide))

Category: Cognitive & Nootropic. Status: Research compound.

An angiotensin IV analog reported 10 million times more potent than BDNF at enhancing synaptic connectivity. Promotes synaptogenesis and spinogenesis.

How it works

Allosteric potentiator of HGF/c-Met signaling driving synaptogenesis, dendritic spine formation, and neuronal survival in hippocampal circuits.

Key facts

  • Molecular weight: 507.6 Da
  • Half-life: 6-12 hours
  • Bioavailability: Moderate (oral/SubQ)
  • Storage: Room temperature (capsule). Solution: -20°C.

Dosing overview

  • Typical dose: 10-20 mg (oral) or 2-5 mg (SubQ)
  • Frequency: Daily
  • Duration: 4-8 weeks
  • Route: Oral or Subcutaneous

Reported benefits

  • Dramatic synaptogenesis
  • Memory improvement
  • Cognitive restoration potential
  • Dendritic spine growth
  • HGF/c-Met activation

Possible side effects

  • Limited safety data
  • Theoretical cancer concern (c-Met)
  • Headache
  • Overstimulation

Research

  • Dihexa as cognitive enhancer via HGF/c-Met (2019): Restored scopolamine-impaired memory at picomolar concentrations through hippocampal synaptogenesis.
  • Angiotensin IV analogs augment hippocampal connectivity (2018): Increased functional synaptic connections by 300% through c-Met dependent spinogenesis.

Community reviews of Dihexa

Rated 4.3 out of 5 from 8 community reviews by ResearchSafe members.

  • halflife_harry rated it 4/5 - Worth adding to the protocol: Dihexa has been a worthwhile addition. I am data-driven and tracked relevant markers before, during, and after. The improvement is measurable and correlates with the intervention timeline. What sets this apart from some compounds I have tried is the consistency. Benefits did not fluctuate wildly or disappear. They built up and maintained. That gives me confidence in the mechanism. Tolerance has been excellent. Nothing in my bloodwork or subjective experience raised any flags. This is the kind of compound that does its job quietly without causing problems. Exactly what you want.
  • n_of_one rated it 4/5 - Genuinely effective after 6 weeks: Been using Dihexa for about 6 weeks and the results are clear. Not overnight dramatic, but a steady, consistent improvement that became undeniable by the end of the first month. The mechanism makes sense based on what I have read in the literature, and my subjective experience matches the expected timeline. Benefits built gradually and plateaued at a good level. Side effects were minimal to none at the dose I used. Followed proper protocols for sourcing, storage, and administration. Would recommend to others who have done their research and have realistic expectations.
  • steady_hand_jen rated it 5/5 - Noticed clear benefits within weeks: Added Dihexa to my protocol about 3 months ago and it has earned its place. The benefits became noticeable around week 2-3 and have been consistent since. What I appreciate about this compound is the predictability. It does what the research suggests it should do, at roughly the timeline you would expect. No surprises, no dramatic swings, just steady improvement. No notable side effects to report at my dose. Sourcing is always the challenge with research compounds, insist on third-party testing. Storage and reconstitution per standard protocols. Plan to continue.
  • deep_science_dee rated it 4/5 - Solid compound with real results: Been using Dihexa for about 2 weeks and the results are clear. Not overnight dramatic, but a steady, consistent improvement that became undeniable by the end of the first month. The mechanism makes sense based on what I have read in the literature, and my subjective experience matches the expected timeline. Benefits built gradually and plateaued at a good level. Side effects were minimal to none at the dose I used. Followed proper protocols for sourcing, storage, and administration. Would recommend to others who have done their research and have realistic expectations.
  • lifter919 rated it 4/5 - Sharper recall on long runs and work calls: For me, the biggest change was recall, I’d be in the middle of a long ultramarathon grind here in PH or handling chemistry work stuff and the right word just came faster, less that annoying fog. Ran it about 6 weeks. Small caveat, it felt a bit too “on” at times, so I kept it modest.
  • avery_v rated it 4/5 - Dihexa fit my writing days, but mornings got a bit sharp: I ran Dihexa for about four months while freelancing from home in the Netherlands, mostly on long writing days where I had to stay mentally switched on without feeling wired. For me it seemed to help with focus and recall, especially when I was juggling research notes, outlines, and revisions for several clients at once. I also liked that it felt more useful than stimulating, which suited my work better than caffeine piling on top of caffeine. The one caveat was that if I took it too early in the day, my mornings could feel a bit too sharp and slightly flat emotionally. Overall, it earned 4 s

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Community discussions about Dihexa

Research and educational reference only. Not medical advice.