Dihexa (Dihexa (N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide))
An angiotensin IV analog reported 10 million times more potent than BDNF at enhancing synaptic connectivity. Promotes synaptogenesis and spinogenesis.
How it works
Allosteric potentiator of HGF/c-Met signaling driving synaptogenesis, dendritic spine formation, and neuronal survival in hippocampal circuits.
Key facts
- Molecular weight: 507.6 Da
- Half-life: 6-12 hours
- Bioavailability: Moderate (oral/SubQ)
- Storage: Room temperature (capsule). Solution: -20°C.
Dosing overview
- Typical dose: 10-20 mg (oral) or 2-5 mg (SubQ)
- Frequency: Daily
- Duration: 4-8 weeks
- Route: Oral or Subcutaneous
Reported benefits
- Dramatic synaptogenesis
- Memory improvement
- Cognitive restoration potential
- Dendritic spine growth
- HGF/c-Met activation
Possible side effects
- Limited safety data
- Theoretical cancer concern (c-Met)
- Headache
- Overstimulation
Research
- Dihexa as cognitive enhancer via HGF/c-Met (2019): Restored scopolamine-impaired memory at picomolar concentrations through hippocampal synaptogenesis.
- Angiotensin IV analogs augment hippocampal connectivity (2018): Increased functional synaptic connections by 300% through c-Met dependent spinogenesis.
Compare Dihexa
Community discussions about Dihexa
- My experience with Dihexa oral and the overstimulation issue? - 4 comments
- Trying oral Dihexa for focus – first week notes and questions - 4 comments
- Dihexa timing shift after three weeks, morning felt too sharp - 6 comments
- My first week on the “Nootropic God” stack – what actually changed - 4 comments
- Dihexa oral for memory gaps – my trial and error with dosing? - 2 comments
- Ask the community about Dihexa
Research and educational reference only. Not medical advice.