DMT vs Psilocin
A side-by-side research comparison of DMT and Psilocin across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | DMT | Psilocin |
|---|---|---|
| Full name | N,N-Dimethyltryptamine | 4-Hydroxy-DMT (active form of psilocybin) |
| Category | Psychedelics | Psychedelics |
| Status | Schedule I (research compound) | Schedule I (research compound) |
| Mechanism | Activates serotonin 5-HT2A receptors, producing vivid changes in perception. When taken orally in ayahuasca, an MAO inhibitor is needed so it is not broken down too quickly. | Directly activates serotonin 5-HT2A receptors. Psilocybin is a "prodrug" that the body converts into psilocin. |
| Molecular weight | 188.27 g/mol | 204.27 g/mol |
| Half-life | ~10-15 minutes | ~1-3 hours |
| Bioavailability | Inhaled/injected (very short); oral only with an MAO inhibitor | Oral |
| Typical dose | Controlled dosing in clinical studies | Varies by individual and setting |
| Frequency | One to a few supervised sessions | Occasional |
| Route | Inhalation or IV in research; oral as ayahuasca | Oral |
DMT reported benefits
- Studied for depression
- Very short experience aids research design
- Used to study consciousness
- Long traditional use as ayahuasca
Psilocin reported benefits
- The active form behind psilocybin
- Studied for depression and anxiety
- Faster onset than psilocybin
- Classic serotonergic psychedelic
Related comparisons
Research and educational reference only. Not medical advice.