DSIP vs Magnesium L-Threonate
A side-by-side research comparison of DSIP and Magnesium L-Threonate across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | DSIP | Magnesium L-Threonate |
|---|---|---|
| Full name | Delta Sleep-Inducing Peptide | Magnesium L-Threonate (Magtein) |
| Category | Sleep & Recovery | Sleep & Recovery |
| Status | Research compound | OTC supplement |
| Mechanism | Modulates GABAergic and glutamatergic neurotransmission in sleep nuclei. Enhances delta wave NREM sleep, normalizes circadian patterns, and reduces cortisol/CRH during sleep. | The L-threonate carrier improves brain magnesium uptake, increasing synaptic density and NMDA receptor regulation. This supports memory, learning, and calmer nervous-system tone, and improves sleep architecture. |
| Molecular weight | 849 Da | 294.5 Da (complex) |
| Half-life | 7-8 minutes | Varies (magnesium homeostasis) |
| Bioavailability | Low (rapid peptidase degradation) | High brain penetrance vs other magnesium salts |
| Typical dose | 100-300 mcg | ~1.5-2 g compound (~144 mg elemental Mg) |
| Frequency | Once, ~30-60 min before bed | Once or split daily |
| Route | Subcutaneous injection | Oral (capsule or powder) |
DSIP reported benefits
- Promotes delta (deep) sleep
- Normalizes sleep architecture
- Reduces stress hormones during sleep
- Non-addictive
- Improved nocturnal GH release
- Circadian normalization
Magnesium L-Threonate reported benefits
- Improved sleep quality
- Cognitive and memory support
- Stress and anxiety reduction
- Brain-penetrant magnesium
- Minimal laxative effect
- Neuroprotective potential
Related comparisons
Research and educational reference only. Not medical advice.