Apigenin vs DSIP
A side-by-side research comparison of Apigenin and DSIP across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Apigenin | DSIP |
|---|---|---|
| Full name | Apigenin (Flavone) | Delta Sleep-Inducing Peptide |
| Category | Sleep & Recovery | Sleep & Recovery |
| Status | OTC supplement | Research compound |
| Mechanism | Binds benzodiazepine sites on GABA-A receptors for mild anxiolytic and sedative effects, and inhibits CD38, an NAD-consuming enzyme, thereby helping preserve cellular NAD+ levels. Also provides antioxidant and anti-inflammatory activity. | Modulates GABAergic and glutamatergic neurotransmission in sleep nuclei. Enhances delta wave NREM sleep, normalizes circadian patterns, and reduces cortisol/CRH during sleep. |
| Molecular weight | 270.24 Da | 849 Da |
| Half-life | ~5-10 hours | 7-8 minutes |
| Bioavailability | Low; enhanced by fat and formulation | Low (rapid peptidase degradation) |
| Typical dose | 50 mg per day | 100-300 mcg |
| Frequency | Once daily (evening) | Once, ~30-60 min before bed |
| Route | Oral capsule | Subcutaneous injection |
Apigenin reported benefits
- Supports sleep onset
- Mild anxiolytic/relaxation
- CD38 inhibition (NAD+ preservation)
- Antioxidant and anti-inflammatory
- Potential anti-cancer research interest
DSIP reported benefits
- Promotes delta (deep) sleep
- Normalizes sleep architecture
- Reduces stress hormones during sleep
- Non-addictive
- Improved nocturnal GH release
- Circadian normalization
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Research and educational reference only. Not medical advice.