EDTA Chelation vs Livagen
A side-by-side research comparison of EDTA Chelation and Livagen across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | EDTA Chelation | Livagen |
|---|---|---|
| Full name | Calcium Disodium EDTA (CaNa2EDTA) | Livagen (Lys-Glu-Asp-Ala Liver/Lymphocyte Bioregulator) |
| Category | Detox & Antioxidant | Detox & Antioxidant |
| Status | FDA Approved (lead poisoning) / Off-label | Research compound (peptide bioregulator) |
| Mechanism | Hexadentate chelator forming stable complexes with Pb²⁺, Cd²⁺, Hg²⁺, and Ca²⁺ from arterial plaque. Metal-EDTA complexes are water-soluble and excreted renally. Also reduces oxidative stress from heavy metal catalyzed Fenton reactions. | As a signal peptide (Lys-Glu-Asp-Ala), it is proposed to decondense chromatin (heterochromatin) in lymphocytes and regulate gene expression in hepatic tissue, supporting liver function and cellular activity. |
| Molecular weight | 374.27 Da (disodium EDTA) | ~460 Da |
| Half-life | ~1.5 hours (IV) | Short (peptide) |
| Bioavailability | ~5% oral; 100% IV | Oral (encapsulated) or subcutaneous |
| Typical dose | 1.5-3g IV over 1-3 hours | ~1-2 capsules/day or short injectable courses |
| Frequency | Weekly or biweekly | Once daily |
| Route | Intravenous infusion | Oral capsule or subcutaneous |
EDTA Chelation reported benefits
- Lead and heavy metal removal
- Reduced cardiovascular events (TACT trial)
- Arterial calcium removal
- Reduced oxidative stress
- Improved vascular function
Livagen reported benefits
- Liver function support
- Lymphocyte chromatin activation (proposed)
- Detox/antioxidant support
- Short course-based protocol
Related comparisons
Research and educational reference only. Not medical advice.