EDTA Chelation (Calcium Disodium EDTA (CaNa2EDTA))
A synthetic amino acid chelator used for heavy metal detoxification. FDA-approved for lead poisoning and investigated for cardiovascular disease (TACT trial). Binds divalent/trivalent metals for renal excretion.
How it works
Hexadentate chelator forming stable complexes with Pb²⁺, Cd²⁺, Hg²⁺, and Ca²⁺ from arterial plaque. Metal-EDTA complexes are water-soluble and excreted renally. Also reduces oxidative stress from heavy metal catalyzed Fenton reactions.
Key facts
- Molecular weight: 374.27 Da (disodium EDTA)
- Half-life: ~1.5 hours (IV)
- Bioavailability: ~5% oral; 100% IV
- Storage: Room temperature. Sterile vials.
Dosing overview
- Typical dose: 1.5-3g IV over 1-3 hours
- Frequency: Weekly or biweekly
- Duration: 20-40 sessions
- Route: Intravenous infusion
Reported benefits
- Lead and heavy metal removal
- Reduced cardiovascular events (TACT trial)
- Arterial calcium removal
- Reduced oxidative stress
- Improved vascular function
Possible side effects
- Mineral depletion (zinc, calcium, magnesium)
- Kidney stress
- Hypocalcemia (rapid infusion)
- Fatigue
- Headache
- Burning at injection site
Research
- TACT trial: EDTA chelation and cardiovascular events (2019): Chelation therapy reduced cardiovascular events by 18% overall and 39% in diabetic patients with prior MI over 5-year follow-up.
- EDTA and heavy metal body burden (2021): 30 IV EDTA sessions reduced urinary provoked lead by 70% and cadmium by 45% in occupationally exposed workers.
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Community discussions about EDTA Chelation
- Thinking about adding EDTA chelation to my detox stack – anyone tried it with NAC or glutathione? - 4 comments
- EDTA Chelation Study: TACT Trial Claims Lower Heart Events, What’s Real? - 6 comments
- Ask the community about EDTA Chelation
Research and educational reference only. Not medical advice.