Epithalon vs GlyNAC
A side-by-side research comparison of Epithalon and GlyNAC across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Epithalon | GlyNAC |
|---|---|---|
| Full name | Epithalon (Epitalon / Epithalone) | Glycine + N-Acetylcysteine |
| Category | Anti-Aging | Anti-Aging |
| Status | Research compound | OTC supplement combination |
| Mechanism | Activates telomerase reverse transcriptase (hTERT) expression for telomere maintenance. Also normalizes circadian rhythm via melatonin regulation and modulates antioxidant enzymes. | Glycine and NAC (a cysteine donor) are the rate-limiting precursors for glutathione. Replenishing both restores intracellular glutathione, lowers oxidative stress, improves mitochondrial fuel oxidation, and reduces inflammation and insulin resistance. |
| Molecular weight | 390.4 Da | Glycine 75.07 Da / NAC 163.19 Da |
| Half-life | 3-4 hours | Glycine ~1 h; NAC ~6 h |
| Bioavailability | High (SubQ) | Glycine high; NAC ~4-10% but effective as cysteine donor |
| Typical dose | 5-10 mg | Glycine ~100 mg/kg + NAC ~100 mg/kg per day |
| Frequency | Daily for 10-20 days | Split 1-2x daily |
| Route | Subcutaneous injection | Oral (powder or capsule) |
Epithalon reported benefits
- Telomerase activation
- Telomere lengthening
- Melatonin normalization
- Improved sleep patterns
- Antioxidant enzyme upregulation
- Potential lifespan extension
GlyNAC reported benefits
- Restores glutathione levels
- Improves mitochondrial function
- Lowers oxidative stress and inflammation
- Better insulin sensitivity
- Improved strength and cognition (elderly)
- Sleep support (glycine)
Related comparisons
Research and educational reference only. Not medical advice.