Epithalon (Epithalon (Epitalon / Epithalone))
A synthetic tetrapeptide based on pineal gland peptide epithalamin. One of few compounds shown to activate telomerase in human somatic cells.
How it works
Activates telomerase reverse transcriptase (hTERT) expression for telomere maintenance. Also normalizes circadian rhythm via melatonin regulation and modulates antioxidant enzymes.
Key facts
- Molecular weight: 390.4 Da
- Half-life: 3-4 hours
- Bioavailability: High (SubQ)
- Storage: Lyophilized: -20°C. Reconstituted: 2-8°C for 14 days.
Dosing overview
- Typical dose: 5-10 mg
- Frequency: Daily for 10-20 days
- Duration: 10-20 day courses, 2-3x per year
- Route: Subcutaneous injection
Protocol notes
- Run as short intensive courses, not continuously: 5-10 mg daily for 10-20 days.
- Repeat the course 2-3 times per year rather than dosing year-round.
Reported benefits
- Telomerase activation
- Telomere lengthening
- Melatonin normalization
- Improved sleep patterns
- Antioxidant enzyme upregulation
- Potential lifespan extension
Possible side effects
- Injection site reaction
- Drowsiness
- Altered sleep timing (initially)
Research
- Peptide regulation of telomerase in human somatic cells (2020): Activated telomerase in fibroblasts, extending proliferative potential by 10 additional doublings.
- Epithalon effects on melatonin and aging markers (2019): Restored nocturnal melatonin peak in elderly and improved antioxidant status.
Compare Epithalon
Community discussions about Epithalon
- Anyone here actually cycled Epithalon? Did your sleep or energy change? - 5 comments
- epithalon nightly drowsiness and injection‑site itch – my 12‑day run - 6 comments
- Combining NMN with the Immortality Stack? - 6 comments
- Thoughts on the Immortality Stack and senolytics - 0 comments
- Feedback on my 4‑week Immortality Stack run – doses and timing - 6 comments
- Ask the community about Epithalon
Research and educational reference only. Not medical advice.