GHK-Cu Topical vs RU-58841
A side-by-side research comparison of GHK-Cu Topical and RU-58841 across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | GHK-Cu Topical | RU-58841 |
|---|---|---|
| Full name | GHK-Cu Copper Peptide (Topical/Scalp) | RU-58841 (PSK-3841) |
| Category | Hair Growth | Hair Growth |
| Status | Cosmetic / Research compound | Research compound |
| Mechanism | Activates genes for hair growth including VEGF, FGF, and nerve growth factor at the follicular level. Stimulates dermal papilla cell proliferation. Extends anagen phase via Wnt/β-catenin pathway activation. Delivers copper for lysyl oxidase (collagen cross-linking). | Non-steroidal androgen receptor antagonist with high binding affinity. Applied topically, penetrates to dermal papilla cells where it blocks DHT-AR complex formation, preventing transcription of hair-miniaturizing genes without systemic antiandrogen effects. |
| Molecular weight | 403.92 Da (with Cu) | 369.34 Da |
| Half-life | ~2-4 hours (topical depot at scalp) | ~1 hour (in skin/plasma); active at receptor for 8-12h |
| Bioavailability | Topical penetration to dermal papilla | Topical only - minimal systemic absorption |
| Typical dose | 1-2 mg/mL in scalp solution or serum | 50-100 mg in 1mL vehicle |
| Frequency | Daily application | Daily application to scalp |
| Route | Topical scalp serum or mesotherapy injection | Topical (dissolved in ethanol/PG vehicle) |
GHK-Cu Topical reported benefits
- Follicle stem cell activation
- Increased hair follicle size
- Scalp angiogenesis
- Collagen remodeling in scalp
- Compatible with all other treatments
- Anti-inflammatory for scalp
RU-58841 reported benefits
- Local anti-androgen (no systemic effects)
- No sexual side effects
- DHT blocking at follicle level
- Can combine with oral finasteride
- Fast-acting (visible in weeks)
Related comparisons
Research and educational reference only. Not medical advice.